4-羟基-3-甲基色烯-2-酮合成路线 （共 19 条）
反应条件
1: 1.) TiCl4, 2.) i-Pr2NEt / 1) CH2Cl2, 0 deg C, 1 h; 2) CH2Cl2, -78 deg C, 1 h; 3) CH2Cl2, 0 deg C --> rt; further reagents
2: 92 percent / aq. HCl / ethanol
View Scheme
参考文献
Morris, Joel; Luke, George P.; Wishka, Donn G.
Journal of Organic Chemistry, 1996 , vol. 61, # 9 p. 3218 - 3220
反应条件
1: 97 percent / NaH / tetrahydrofuran / Heating
2: 92 percent / TFA / toluene / 1 h / Heating
View Scheme
参考文献
Kalinin, Alexey V.; Da Silva, Alcides J. M.; Lopes, Claudio C.; Lopes, Rosangela S. C.; Snieckus, Victor
Tetrahedron Letters, 1998 , vol. 39, # 28 p. 4995 - 4998
反应条件
hydrogenchloride; lithium diisopropyl amide
Yield given. Multistep reaction;
参考文献
Davis, Sharon E.; Church, A. Cameron; Tummons, Rebecca C.; Beam, Charles F.
Journal of Heterocyclic Chemistry, 1997 , vol. 34, # 4 p. 1159 - 1162
参考文献
Ziegler; Junek
Monatshefte fuer Chemie, 1956 , vol. 87, p. 212,216
参考文献
Urbain; Mentzer
Bulletin de la Societe Chimique de France, 1944 , vol. <5> 11, p. 171,173
参考文献
Ziegler; Junek
Monatshefte fuer Chemie, 1955 , vol. 86, p. 29,36
Monatshefte fuer Chemie, 1956 , vol. 87, p. 212,216
参考文献
Ghosh
Journal of the Indian Chemical Society, 1947 , vol. 24, p. 321
反应条件
1: phosphorus (V)-chloride
2: aq.-ethanolic hydrochloric acid; zinc-powder
View Scheme
参考文献
Mentzer; Meunier
Bulletin de la Societe Chimique de France, 1943 , vol. <5> 10, p. 356,360
反应条件
1: 1.) triethylamine, 2.) Cl2 / 1) THF; 2) ice-cooling, 30 min
2: 76 percent / H2O / dioxane / 12 h / Ambient temperature
View Scheme
参考文献
Silverman
Journal of the American Chemical Society, 1980 , vol. 102, # 16 p. 5421 - 5423
