2-氨基-5-[(4-氟苄基)氨基]-1-硝基苯合成路线 （共 7 条）
反应条件
sodium tetrahydroborate in 1,4-dioxane; methanol T=20°C; 2 h;
参考文献
Hu, Hai-Ning; Zhou, Ping-Zheng; Chen, Fei; Li, Min; Nan, Fa-Jun; Gao, Zhao-Bing
Acta Pharmacologica Sinica, 2013 , vol. 34, # 10 p. 1359 - 1366
反应条件
sodium tetrahydroborate in water; isopropyl alcohol T=20°C; SolventTime;
参考文献
ARCH PHARMALABS LIMITED; MANDAL, Arun Kanti; RANBHAN, Kamlesh Jayantilal; SAXENA, Sudhanshu; GAIKWAD, Sanjay Ramrao; SARJEKAR, Pushpalata Balkrishna
Patent: WO2013/11518 A1, 2013 ;
Location in patent: Page/Page column 55-56 ;
反应条件
1: isopropyl alcohol / 75 °C 2: sodium hydroxide; sodium tetrahydroborate / 75 °C View Scheme
反应条件
1: isopropyl alcohol / 75 °C 2: sodium hydroxide; sodium tetrahydroborate / 75 °C View Scheme
反应条件
hydrogen in methanol T=20°C; P=760.051 Torr; 3 h;
参考文献
Acta Pharmacologica Sinica, , vol. 34, # 10 p. 1359 - 1366
反应条件
sodium ethanolate T=20 - 25°C; 1.5 h;
参考文献
WO2012/98075 A1, ;
Page/Page column 7 ;
反应条件
1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 20 - 30 °C / |Inert atmosphere 2: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 20 - 70 °C / |Inert atmosphere 3: hydrogen; 5 palladium on charcoal / 1,4-dioxane; ethanol / 20 °C / 760.05 Torr View Scheme
参考文献
OLON S.P.A.; LONGONI, Davide; FRIGOLI, Samuele; ALPEGIANI, Marco
Patent: WO2013/114315 A1, 2013 ;
