(2E)-3-(4-氯-2-硝基苯基)-2-丙烯酸甲酯合成路线 （共 1 条）
反应条件
1: 71 percent / Zn, glacial AcOH / ethanol / 4 h / 60 °C 2: Et3N / tetrahydrofuran; toluene / 0.33 h / 0 °C 3: 1.) t-BuOK / 1.) THF, 0 deg C, 2.) THF, toluene, 0 deg C, 1 h 4: 14 percent / NaH / methanol / 14 h / Ambient temperature 5: 52 percent / aq. NaOH / methanol / 14 h / Ambient temperature View Scheme
参考文献
Carling; Leeson; Moore; Smith; Moyes; Mawer; Thomas; Chan; Baker; Foster; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 22 p. 3397 - 3408
