(苯基亚甲基)氨基甲酸叔丁酯合成路线 （共 35 条）
反应条件
lithium methanolate; trifluoroacetic acid in N,N-dimethyl-formamide T=0°C; Diels-Alder reaction; 24 h;
参考文献
Heterocycles, , vol. 73, # C p. 255 - 261
反应条件
1: potassium hydroxide; (S)-N-(4-bromobenzyl)-N,N,3,3-tetramethyl-2-(3-(4-nitrophenyl)thioureido)butan-1-ammonium acetate / dichloromethane / 1 h / -30 °C / |Inert atmosphere 2: sodium nitrite; acetic acid / dimethyl sulfoxide / 24 h / 40 °C 3: trifluoroacetic acid / dichloromethane / 24 h 4: sodium tetrahydroborate; iodine / tetrahydrofuran / 19 h / 0 °C / |Reflux 5: triethylamine / dimethyl sulfoxide / 2 h / 100 °C / |Irradiation View Scheme
参考文献
Wang, Hong-Yu; Chai, Zhuo; Zhao, Gang
Tetrahedron, 2013 , vol. 69, # 25 p. 5104 - 5111
反应条件
potassium carbonate in tetrahydrofuran
12 h; Heating;
参考文献
Mita, Tsuyoshi; Higuchi, Yuki; Sato, Yoshihiro
Organic Letters, 2011 , vol. 13, # 9 p. 2354 - 2357
反应条件
1: With formic acid; benzenesulphinic acid sodium salt in methanol; water
T=25°C; Inert atmosphere;
2: With potassium carbonate in tetrahydrofuran
12 h; Inert atmosphereReflux;
参考文献
Chen, Dongxu; Chen, Xiaoyi; Du, Taiping; Kong, Lichun; Zhen, Renwei; Zhen, Shaocheng; Wen, Yihang; Zhu, Gangguo
Tetrahedron Letters, 2010 , vol. 51, # 39 p. 5131 - 5133
反应条件
1: formic acid / methanol; H2O / 72 h / 20 °C
2: anhydrous potassium carbonate / tetrahydrofuran / 17 h / Heating
View Scheme
参考文献
Palomo, Claudio; Oiarbide, Mikel; Halder, Rajkumar; Laso, Antonio; Lopez, Rosa
Angewandte Chemie - International Edition, 2006 , vol. 45, # 1 p. 117 - 120
反应条件
potassium hydride in dichloromethane
T=20°C; 1 h;
参考文献
Enders, Dieter; Oberboersch, Stefan
Synlett, 2002 , # 3 p. 471 - 473
反应条件
1: formic acid / methanol; water / 60 h / 20 °C / Inert atmosphere
2: potassium carbonate; sodium sulfate / tetrahydrofuran / 12 h / Inert atmosphere; Reflux
View Scheme
参考文献
Mita, Tsuyoshi; Chen, Jianyang; Sugawara, Masumi; Sato, Yoshihiro
Angewandte Chemie - International Edition, 2011 , vol. 50, # 6 p. 1393 - 1396
反应条件
in toluene
110 h; Heating;
参考文献
Vidal, Joelle; Guy, Laure; Sterin, Sebastien; Collet, Andre
Journal of Organic Chemistry, 1993 , vol. 58, # 18 p. 4791 - 4793
反应条件
1: LiMCPBA / CH2Cl2 / 2 h / -78 °C
2: CD2Cl2 / -94 °C
3: toluene / 111 h / Heating
View Scheme
参考文献
Vidal, Joelle; Damestoy, Stephanie; Guy, Laure; Hannachi, Jean-Christophe; Aubry, Andre; Collet, Andre
Chemistry - A European Journal, 1997 , vol. 3, # 10 p. 1691 - 1709
反应条件
silver(I) acetate; toluene-4-sulfonic acid
T=20°C; 0.166667 h; Inert atmosphere;
参考文献
George, Nicolas; Bekkaye, Mathieu; Masson, Geraldine; Zhu, Jieping
European Journal of Organic Chemistry, 2011 , # 20-21 p. 3695 - 3699
