(苯基亚甲基)氨基甲酸叔丁酯合成路线 （共 35 条）
反应条件
in dichloromethane
T=-78°C;
参考文献
Brown, Richard C.D.; Fisher, Martyn L.; Brown, Lynda J.
Organic and Biomolecular Chemistry, 2003 , vol. 1, # 15 p. 2699 - 2709
反应条件
1: 92 percent / diethyl ether
2: toluene / 111 h / Heating
View Scheme
参考文献
Vidal, Joelle; Damestoy, Stephanie; Guy, Laure; Hannachi, Jean-Christophe; Aubry, Andre; Collet, Andre
Chemistry - A European Journal, 1997 , vol. 3, # 10 p. 1691 - 1709
反应条件
1: CD2Cl2 / -94 °C
2: toluene / 111 h / Heating
View Scheme
参考文献
Vidal, Joelle; Damestoy, Stephanie; Guy, Laure; Hannachi, Jean-Christophe; Aubry, Andre; Collet, Andre
Chemistry - A European Journal, 1997 , vol. 3, # 10 p. 1691 - 1709
反应条件
1: ammonium hydroxide / ethanol; water / 18.58 h / -10 - 20 °C
2: water; methanol; formic acid / 72 h / 20 °C
3: caesium carbonate / dichloromethane / |Reflux
View Scheme
参考文献
Best, Daniel; Kujawa, Szymon; Lam, Hon Wai
Journal of the American Chemical Society, 2012 , vol. 134, # 44 p. 18193 - 18196
参考文献
Vidal, Joelle; Guy, Laure; Sterin, Sebastien; Collet, Andre
Journal of Organic Chemistry, 1993 , vol. 58, # 18 p. 4791 - 4793
参考文献
Vidal, Joelle; Guy, Laure; Sterin, Sebastien; Collet, Andre
Journal of Organic Chemistry, 1993 , vol. 58, # 18 p. 4791 - 4793
反应条件
1: With (DHQ)2PYR in chloroform
T=-40°C; Mannich-type reaction; 20 h; Inert atmosphere;
2: With chloro-trimethyl-silane; magnesium in methanol; ethylene dibromide
T=0 - 20°C; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Gonzalez, Pedro B.; Lopez, Rosa; Palomo, Claudio
Journal of Organic Chemistry, 2010 , vol. 75, # 11 p. 3920 - 3922
反应条件
titanium tetra-n-butoxide; water; N-(2'-hydroxyphenyl)methyl-(S)-2-amino-3,3-dimethyl-butan-1-ol in toluene; butan-1-ol
T=20°C; 0.25 h; optical yield given as percent eeenantioselective reaction;
参考文献
Seayad, Abdul Majeed; Ramalingam, Balamurugan; Yoshinaga, Kazuhiko; Nagata, Takushi; Chai, Christina L. L.
Organic Letters, 2010 , vol. 12, # 2 p. 264 - 267
反应条件
1: 81 percent / ethyldiisopropylamine; anhydrous zinc triflate; (-)-(1R,2S)-N-methylephedrine / molecular sieves 4 Angstroem / -20 °C
2: sodium nitrite; acetic acid / dimethylsulfoxide / 24 h / 40 °C
3: 135 mg / methanol; benzene / 0.33 h / 20 °C
View Scheme
参考文献
Palomo, Claudio; Oiarbide, Mikel; Halder, Rajkumar; Laso, Antonio; Lopez, Rosa
Angewandte Chemie - International Edition, 2006 , vol. 45, # 1 p. 117 - 120
反应条件
1: benzaldehyde N-boc imine With C40H26Br2N2O2; diethylaluminium chloride; triethylamine in hexane; dichloromethane; toluene
0.0833333 h; Inert atmosphere;
2: [(Cyanocarbonyl)oxy]ethane in isopropyl alcohol
T=20°C; Strecker synthesis; 12 h; optical yield given as percent eeenantioselective reaction;
参考文献
Abell, Joshua P.; Yamamoto, Hisashi
Journal of the American Chemical Society, 2009 , vol. 131, # 42 p. 15118 - 15119
