(苯基亚甲基)氨基甲酸叔丁酯合成路线 （共 35 条）
反应条件
Hua Cat in dichloromethane
T=20°C; Mannich reaction; 13 h; optical yield given as percent eeenantioselective reaction;
参考文献
Yang, Hua; Carter, Rich G.
Journal of Organic Chemistry, 2009 , vol. 74, # 5 p. 2246 - 2249
反应条件
(3S,4S)-3-(tert-butyldimethylsilyloxy)-4-(trifluoromethylsulfonamido)pyrrolidine
T=20°C; 44 h;
参考文献
Martin-Rapun, Rafael; Fan, Xinyuan; Sayalero, Sonia; Bahramnejad, Mahboubeh; Cuevas, Felix; Pericas, Miquel A.
Chemistry - A European Journal, 2011 , vol. 17, # 32 p. 8780 - 8783
反应条件
1: potassium hydroxide; (S)-N-(4-bromobenzyl)-N,N,3,3-tetramethyl-2-(3-(4-nitrophenyl)thioureido)butan-1-ammonium acetate / dichloromethane / 1 h / -30 °C / |Inert atmosphere
2: sodium nitrite; acetic acid / dimethyl sulfoxide / 24 h / 40 °C
3: trifluoroacetic acid / dichloromethane / 24 h
View Scheme
参考文献
Wang, Hong-Yu; Chai, Zhuo; Zhao, Gang
Tetrahedron, 2013 , vol. 69, # 25 p. 5104 - 5111
反应条件
1: With 2,5,6,7-tetrahydro-2-phenyl-3H-pyrrolo[2,1-c]-1,2,4-triazol-3-ylidenium chloride; (Ph)2SiH2; sodium hydride in N,N-dimethyl-formamide; mineral oil
T=20°C;
2: With tetrabutyl ammonium fluoride in tetrahydrofuran; N,N-dimethyl-formamide
0.5 h;
参考文献
Zhao, Qiwu; Curran, Dennis P.; Malacria, Max; Fensterbank, Louis; Goddard, Jean-Philippe; Lacote, Emmanuel
Synlett, 2012 , # 3 p. 433 - 437
反应条件
1: benzaldehyde N-boc imine With TMS-SnBu3; cesium fluoride in N,N-dimethyl-formamide
T=20°C; 0.0833333 h; Inert atmosphere;
2: carbon dioxide in N,N-dimethyl-formamide
T=100°C; P=7500.75 Torr; 3 h; Autoclave;
3: diazomethane Further stages;
参考文献
Mita, Tsuyoshi; Chen, Jianyang; Sugawara, Masumi; Sato, Yoshihiro
Angewandte Chemie - International Edition, 2011 , vol. 50, # 6 p. 1393 - 1396
