(3R)-3-(N-叔丁氧羰基氨基)-1-氯-4-苯基-2-丁酮合成路线 （共 8 条）
反应条件
hydrogenchloride in 1,4-dioxane; diethyl ether; water T=0°C; 0.5 h;
参考文献
The Procter and Gamble Company
Patent: US2006/128613 A1, 2006 ;
Location in patent: Page/Page column 54-55 ;
US 20060128613 A1
反应条件
methanesulfonyl chloride; lithium chloride in tetrahydrofuran T=0°C; 2 h; Heating / reflux;
参考文献
WO2007/15805 A1, ;
Page/Page column 43 ;
反应条件
1: With methyl-magnesium chloride in tetrahydrofuran T=10°C; 0.5 h; Inert atmosphere; 2: With methyl-magnesium chloride; diisopropylamine in tetrahydrofuran T=10°C; 2.75 h; Reflux;
参考文献
Babu, Kilaru Ravendra; Rao, Valasani Koteswara; Sudhakar, Yellapu; Raju, Chamarthi Naga
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2012 , vol. 51, # 6 p. 849 - 854
反应条件
1: 4-methylmorpholine / tetrahydrofuran / 0.33 h / -25 - -20 °C 2: diethyl ether / a) 0 deg C, 2 h, b) RT, overnight 3: HCl / dioxane / 1 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 12 p. 1758 - 1768
反应条件
1: diethyl ether / a) 0 deg C, 2 h, b) RT, overnight 2: HCl / dioxane / 1 h / 0 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 12 p. 1758 - 1768
反应条件
1.1: thionyl chloride / 5 h / Reflux 2.1: sodium hydrogencarbonate / 16 h / 20 °C 3.1: methyl-magnesium chloride / tetrahydrofuran / 0.5 h / 10 °C / Inert atmosphere 3.2: 2.75 h / 10 °C / Reflux View Scheme
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 51, # 6 p. 849 - 854
反应条件
1.1: sodium hydrogencarbonate / 16 h / 20 °C 2.1: methyl-magnesium chloride / tetrahydrofuran / 0.5 h / 10 °C / Inert atmosphere 2.2: 2.75 h / 10 °C / Reflux View Scheme
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 51, # 6 p. 849 - 854
反应条件
1: aluminum isopropoxide; isopropyl alcohol / 3 h / Reflux 2: sodium hydroxide / acetone / 1.5 h / 20 °C View Scheme
参考文献
Babu, Kilaru Ravendra; Rao, Valasani Koteswara; Sudhakar, Yellapu; Raju, Chamarthi Naga
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2012 , vol. 51, # 6 p. 849 - 854
