反应条件
1: 1)nBuLi / 1) THF, hexane, a) -25 deg C, 3 h, b) -5 deg C, 0.5 h, 2) THF, -5 deg C to rt, overnight
2: 70 percent / BBr3 / CH2Cl2 / 1) -30 deg C, 2.5 h, 2) -30 deg C to rt, overnight
View Scheme
参考文献
Brown; Bersntein; Cronk; Dossett; Hebbel; Maduskuie Jr.; Shapiro; Vacek; Yee; Willard; Krell; Snyder
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 807 - 826