反应条件
1: 1.) tetramethylethylenediamine (TMEDA), BuLi / 1.) petroleum ether, hexane, RT, 0.5 h, 2.) petroleum ether, hexane, RT, 0.5 h
2: 94 percent / Br2 / CH2Cl2 / 1 h / Ambient temperature
3: 1.) diisopropylamine, BuLi / 1.) THF, hexane, 1 min, 2.) THF, hexane, 0.5 h
4: LiAlH4 / tetrahydrofuran / 1.5 h / Heating
View Scheme
参考文献
Jacob, Peyton; Shulgin, Alexander T.
Journal of Medicinal Chemistry, 1984 , vol. 27, # 7 p. 881 - 888
