反应条件
1.1: N,N,N',N,-tetramethylethylenediamine; n-butyllithium / tetrahydrofuran / 0.5 h / 0 - 5 °C / |Inert atmosphere; |Large scale
1.2: 1 h / 10 °C / |Inert atmosphere; |Large scale
2.1: AlCl3, aluminium chloride / dichloromethane / 5 h / -15 - 20 °C / |Inert atmosphere; |Large scale
2.2: 25 °C / |Inert atmosphere; |Large scale
3.1: potassium carbonate / N,N-dimethyl-formamide / 70 °C / |Inert atmosphere; |Large scale
4.1: water / N,N-dimethyl-formamide / 10 h / 120 °C / |Inert atmosphere; |Large scale
View Scheme
参考文献
Haight, Anthony R.; Bailey, Anne E.; Baker, William S.; Cain, Michael H.; Copp, Richard R.; Demattei, John A.; Ford, Kelley L.; Henry, Rodger F.; Hsu, Margaret C.; Keyes, Robert F.; King, Steven A.; McLaughlin, Maureen A.; Melcher, Laura M.; Nadler, William R.; Oliver, Patricia A.; Parekh, Shyamal I.; Patel, Hemant H.; Seif, Louis S.; Staeger, Mike A.; Wayne, Gregory S.; Wittenberger, Steven J.; Zhang, Weijiang
Organic Process Research and Development, 2004 , vol. 8, # 6 p. 897 - 902
