(R)-1,2,3,4-四氢-1-异喹啉甲酸合成路线 （共 7 条）
反应条件
lipase B from Candida albicans; ammonium acetate in ethanol; water T=3°C; pH=8.0; 24 h; Enzymatic reaction;
参考文献
Paal, Tihamer A.; Liljeblad, Arto; Kanerva, Liisa T.; Forro, Eniko; Fueloep, Ferenc
European Journal of Organic Chemistry, 2008 , # 31 p. 5269 - 5276
反应条件
water; n-dipropylamine; lipase B from Candida antarctica in toluene; acetonitrile T=25°C; 192 h; Enzymatic reaction;
参考文献
Paal, Tihamer A.; Forro, Eniko; Liljeblad, Arto; Kanerva, Liisa T.; Fueloep, Ferenc
Tetrahedron Asymmetry, 2007 , vol. 18, # 12 p. 1428 - 1433
反应条件
1: 99 percent / H2 / Pt/C / acetic acid / 24 h / 25 °C / 45004.5 Torr 2: 54 percent / SOCl2 / 1 h / Heating 3: 80 percent / lipase B from Candida antarctica; dipropylamine; water / acetonitrile; toluene / 192 h / 25 °C / Enzymatic reaction View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 18, # 12 p. 1428 - 1433
反应条件
water; lipase B from Candida antarctica in di-isopropyl ether T=3°C; 92 h; Enzymatic reaction;
参考文献
Tetrahedron Asymmetry, , vol. 18, # 12 p. 1428 - 1433
反应条件
1: 54 percent / SOCl2 / 1 h / Heating 2: 80 percent / lipase B from Candida antarctica; dipropylamine; water / acetonitrile; toluene / 192 h / 25 °C / Enzymatic reaction View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 18, # 12 p. 1428 - 1433
参考文献
NEUROCRINE BIOSCIENCES, INC.
Patent: WO2005/7164 A1, 2005 ;
Location in patent: Page 55 ;
WO 2005/007164 A1
反应条件
sodium hydroxide in 1,4-dioxane; water T=0°C; pH 10.7;
参考文献
Hruby, Victor J.; Cody, Wayne L.; Castrucci, Ana Maria de Lauro; Hadley, Mac E.
Collection of Czechoslovak Chemical Communications, 1988 , vol. 53, # 11A p. 2549 - 2573
