1-[3-(1,3-二氧杂烷-2-基)苯基]-1H-咪唑合成路线 （共 4 条）
反应条件
1: 1H-imidazole With sodium hydride in N,N-dimethyl-formamide; mineral oil T=20°C; 0.333333 h; 2: 1-bromo-2-(1,3-dioxolan-2-yl)-benzene With copper in N,N-dimethyl-formamide; mineral oil 5 h; Reflux;
参考文献
Maligaspe, Eranda; Kumpulainen, Tatu; Lemmetyinen, Helge; Tkachenko, Nikolai V.; Subbaiyan, Navaneetha K.; Zandler, Melvin E.; D'Souza, Francis
Journal of Physical Chemistry A, 2010 , vol. 114, # 1 p. 268 - 277
反应条件
copper; sodium hydride 1.) DMF, RT, 2.) DMF, 150 deg C, 4 h; Yield given. Multistep reaction;
参考文献
Cozzi, Paolo; Carganico, Germano; Fusar, Domenico; Grossoni, Mauro; Menichincheri, Maria; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 20 p. 2964 - 2972
反应条件
1: 96 percent / 1 N aq. HCl / 2 h / Ambient temperature 2: 84 percent / 30percent aq. NH4OH / ethanol / 6 h / Heating View Scheme
参考文献
Cozzi, Paolo; Carganico, Germano; Fusar, Domenico; Grossoni, Mauro; Menichincheri, Maria; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 20 p. 2964 - 2972
反应条件
hydrogenchloride 2 h; Ambient temperature;
参考文献
Cozzi, Paolo; Carganico, Germano; Fusar, Domenico; Grossoni, Mauro; Menichincheri, Maria; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 20 p. 2964 - 2972
