4-碘-2-(3-甲基-2-丁烯基)-苯酚合成路线 （共 7 条）
反应条件
1: 4-hydroxyiodobenzene With sodium in diethyl ether T=0°C; 3 h; 2: prenyl bromide in diethyl ether T=25°C; 8 h;
参考文献
Lykakis, Ioannis N.; Efe, Christina; Gryparis, Charis; Stratakis, Manolis
European Journal of Organic Chemistry, 2011 , # 12 p. 2334 - 2338
反应条件
10percent NaOH T=20°C; 5 h;
参考文献
Uto, Yoshihiro; Hirata, Akihiko; Fujita, Tomoya; Takubo, Syunsuke; Nagasawa, Hideko; Hori, Hitoshi
Journal of Organic Chemistry, 2002 , vol. 67, # 7 p. 2355 - 2357
反应条件
palladium diacetate; triethylamine; tris-(o-tolyl)phosphine in N,N-dimethyl-formamide
T=100°C; Heck reaction; 40 h; Inert atmosphere;
参考文献
Lykakis, Ioannis N.; Efe, Christina; Gryparis, Charis; Stratakis, Manolis
European Journal of Organic Chemistry, 2011 , # 12 p. 2334 - 2338
反应条件
triethylamine; bis-triphenylphosphine-palladium(II) chloride in acetonitrile
T=100°C; 14 h;
参考文献
Bates, Roderick W.; Gabel, Christine J.; Ji, Jianhua; Rama-Devi, Thota
Tetrahedron, 1995 , vol. 51, # 30 p. 8199 - 8212
反应条件
1: 91 percent / Et3N, DMAP / CH2Cl2
2: 96 percent / (o-tol)3P, Et3N / Pd(OAc)2 / toluene / 20 h / Heating
3: 89 percent / K2CO3 / methanol
View Scheme
参考文献
Bates; Gabel
Tetrahedron Letters, 1993 , vol. 34, # 22 p. 3547 - 3550
反应条件
1: 96 percent / 4-(dimethylamino)pyridine / CH2Cl2 / 4 h / Heating
2: 93 percent / Et3N; tri(o-tolyl)phosphine / Pd(OAc)2 / toluene / 20 h / Heating
3: 74 percent / KOH / H2O; methanol / 3 h / Heating
View Scheme
参考文献
Uto, Yoshihiro; Ae, Shutaro; Koyama, Daisuke; Sakakibara, Mitsutoshi; Otomo, Naoki; Otsuki, Mamoru; Nagasawa, Hideko; Kirk, Kenneth L.; Hori, Hitoshi
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 16 p. 5721 - 5728
反应条件
1: 96 percent / 4-(dimethylamino)pyridine / CH2Cl2 / 4 h / Heating
2: 93 percent / Et3N; tri(o-tolyl)phosphine / Pd(OAc)2 / toluene / 20 h / Heating
3: 74 percent / KOH / H2O; methanol / 3 h / Heating
View Scheme
参考文献
Uto, Yoshihiro; Ae, Shutaro; Koyama, Daisuke; Sakakibara, Mitsutoshi; Otomo, Naoki; Otsuki, Mamoru; Nagasawa, Hideko; Kirk, Kenneth L.; Hori, Hitoshi
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 16 p. 5721 - 5728
