sodium hydrogencarbonate in tetrahydrofuran; water T=20°C; 3 h;

1: <bis(trifluoroacetoxy)iodo>benzene / acetonitrile; H2O / 144 h / Ambient temperature 2: DIEA / dioxane / 3 h / Ambient temperature 3: 78 percent / 1 N NaOH / methanol / 2 h / Ambient temperature 4: 1) TFA, 2) aq. Na2CO3 / 2) dioxane, 4 deg C, 2 h View Scheme

1: DIEA / dioxane / 3 h / Ambient temperature 2: 78 percent / 1 N NaOH / methanol / 2 h / Ambient temperature 3: 1) TFA, 2) aq. Na2CO3 / 2) dioxane, 4 deg C, 2 h View Scheme

1: 78 percent / 1 N NaOH / methanol / 2 h / Ambient temperature 2: 1) TFA, 2) aq. Na2CO3 / 2) dioxane, 4 deg C, 2 h View Scheme

1: C6H5I(CF3COO)2, pyridine / dimethylformamide; H2O / 4 h / Ambient temperature 2: NEt3 / acetone; H2O View Scheme

triethylamine in water; acetone

sodium carbonate; trifluoroacetic acid 2) dioxane, 4 deg C, 2 h; Yield given. Multistep reaction;