3,5-二-叔丁基-4-(甲氧基甲氧基)苯甲醛合成路线 （共 5 条）
反应条件
N-ethyl-N,N-diisopropylamine in 1,2-dichloro-ethane T=20°C; 18 h; Heating / reflux;
参考文献
Centaur Pharmaceuticals, Inc.
Patent: US6342523 B1, 2002 ;
Location in patent: Page column 20-21 ;
反应条件
N-ethyl-N,N-diisopropylamine in ethyl acetate; 1,2-dichloro-ethane; pentane
参考文献
Waterbury, L. David; Wood, Paul L.; Khan, M. Amin; Upasani, Ravindra B.
Patent: US2002/165274 A1, 2002 ;
反应条件
hydrogenchloride in acetone Hydrolysis; 1 h;
参考文献
Inagaki, Masanao; Tsuri, Tatsuo; Jyoyama, Hirokuni; Ono, Takashi; Yamada, Katsutoshi; Kobayashi, Mika; Hori, Yozo; Arimura, Akinori; Yasui, Kiyoshi; Ohno, Kouji; Kakudo, Shinji; Koizumi, Kenzo; Suzuki, Ryuji; Kato, Miyako; Kawai, Shinichi; Matsumoto, Saichi
Journal of Medicinal Chemistry, 2000 , vol. 43, # 10 p. 2040 - 2048
反应条件
1.1: NaH / tetrahydrofuran; dimethylformamide / 0.17 h 1.2: 80 percent / tetrahydrofuran; dimethylformamide / 1 h 2.1: 100 percent / aq. HCl / acetone / 1 h View Scheme
参考文献
Inagaki, Masanao; Tsuri, Tatsuo; Jyoyama, Hirokuni; Ono, Takashi; Yamada, Katsutoshi; Kobayashi, Mika; Hori, Yozo; Arimura, Akinori; Yasui, Kiyoshi; Ohno, Kouji; Kakudo, Shinji; Koizumi, Kenzo; Suzuki, Ryuji; Kato, Miyako; Kawai, Shinichi; Matsumoto, Saichi
Journal of Medicinal Chemistry, 2000 , vol. 43, # 10 p. 2040 - 2048
反应条件
1.1: p-TsOH / benzene / 48 h / Heating 2.1: NaH / tetrahydrofuran; dimethylformamide / 0.17 h 2.2: 80 percent / tetrahydrofuran; dimethylformamide / 1 h 3.1: 100 percent / aq. HCl / acetone / 1 h View Scheme
参考文献
Amorati, Riccardo; Lucarini, Marco; Mugnaini, Veronica; Pedulli, Gian Franco; Roberti, Marinella; Pizzirani, Daniela
Journal of Organic Chemistry, 2004 , vol. 69, # 21 p. 7101 - 7107
