4-(4-氨基苯基)丁酸合成路线 （共 15 条）
反应条件
hydrogen; 10percent Pd/C in methanol P=2068.65 Torr; 1 h;
参考文献
Zou; Kopajtic; Katz; Wirtz; Justice Jr.; Newman
Journal of Medicinal Chemistry, 2001 , vol. 44, # 25 p. 4453 - 4461
反应条件
1: nitric acid / -30 - -20 °C 2: Raney nickel; ethanol / Hydrogenation View Scheme
参考文献
Journal of the American Chemical Society, , vol. 71, p. 779
反应条件
1: H2 / Pd-C / dioxane 2: KOH / ethanol / Heating View Scheme
参考文献
Gazzetta Chimica Italiana, , vol. 97, p. 654 - 664
反应条件
potassium hydroxide in ethanol Heating;
参考文献
Gazzetta Chimica Italiana, , vol. 97, p. 654 - 664
反应条件
Oxonereg;; sodium hydroxide in water; acetone T=8°C; buffer (NaHCO3);
参考文献
Webb, Kevin S.; Seneviratne, Viran
Tetrahedron Letters, 1995 , vol. 36, # 14 p. 2377 - 2378
反应条件
sulfuric acid 1.5 h; Reflux;
参考文献
TETRA DISCOVERY PARTNERS, LLC.; GURNEY, Mark, E.; HAGEN, Timothy, J.; MO, Xuesheng; VELLEKOOP, A.; ROMERO, Donna, L.; CAMPBELL, Robert, F.; WALKER, Joel, R.; ZHU, Lei
Patent: WO2014/66659 A1, 2014 ;
Location in patent: Paragraph 0722 ;
反应条件
HCl conc.; sodium carbonate in methanol
参考文献
MethylGene, Inc.
Patent: US6541661 B1, 2003 ;
反应条件
sulfuric acid; sodium carbonate in methanol
参考文献
LABORATORIOS MENARINI S.A.
Patent: EP775133 B1, 2001 ;
反应条件
in tetrahydrofuran; methanol; hexane; dichloromethane T=0 - 20°C; 1 h;
参考文献
TETRA DISCOVERY PARTNERS, LLC.; GURNEY, Mark, E.; HAGEN, Timothy, J.; MO, Xuesheng; VELLEKOOP, A.; ROMERO, Donna, L.; CAMPBELL, Robert, F.; WALKER, Joel, R.; ZHU, Lei
Patent: WO2014/66659 A1, 2014 ;
Location in patent: Paragraph 0548 ;
反应条件
acetic acid T=30 - 80°C; 18 h; Sonication;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 18, # 22 p. 5926 - 5931
