4-(4-氨基苯基)丁酸合成路线 （共 15 条）
反应条件
1: With sulfuric acid; sodium nitrite T=0°C; Diazotization; 0.75 h; 2: With sodium azide T=0°C; Substitution; 0.666667 h;
参考文献
Halmos, Therese; Turek, Joseph W.; Le Breton, Guy C.; Antonakis, Kostas
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 20 p. 2963 - 2968
反应条件
triethylamine in 1,4-dioxane; water T=20°C; 24 h;
参考文献
Tetrahedron, , vol. 61, # 45 p. 10643 - 10651
反应条件
1: With sodium hydrogencarbonate in tetrahydrofuran T=20°C; 2: With hydrogenchloride in tetrahydrofuran; water
参考文献
Myriad Pharmaceuticals, Inc.
Patent: US2004/14763 A1, 2004 ;
Location in patent: Page 23 ;
反应条件
hydrogenchloride; sulfuric acid in ethanol; dichloromethane; water
参考文献
Pfizer Inc.
Patent: US6288120 B1, 2001 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=25°C; 2 h;
参考文献
Nicolaou; Sugita; Baran; Zhong
Journal of the American Chemical Society, 2002 , vol. 124, # 10 p. 2221 - 2232
