2-(2-硝基苯基)乙醇合成路线 （共 40 条）
反应条件
1: 82 percent / pyridine / 3 h / 20 °C 2: 86 percent / 1-methyl-pyrrolidin-2-one / 1 h / 90 - 100 °C 3: 100 percent / aqueous sulfuric acid / 4.5 h / 130 - 135 °C View Scheme
参考文献
Liu, Bin; Hu, Longqin
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 18 p. 3889 - 3899
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane T=0°C; 0.75 h;
参考文献
Bristol-Myers Squibb Company
Patent: US2007/259851 A1, 2007 ;
Location in patent: Page/Page column 108 ;
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane T=0°C;
参考文献
MERCK and CO., INC.
Patent: WO2005/807 A2, 2005 ;
Location in patent: Page 38 ;
WO 2005/000807 A2
反应条件
1: hydrogen / paraffin oil / 1.5 h / 110 °C / 15001.5 Torr
2: Raney Ni / 220 °C / Large scale reaction
View Scheme
参考文献
Guo, Xianghai; Peng, Zhiliang; Jiang, Shende; Shen, Jiaxiang
Synthetic Communications, 2011 , vol. 41, # 14 p. 2044 - 2052
反应条件
potassium hydroxide; [{(η5-C5Me5)IrCl}2(μ-Cl)2]
T=120°C; 48 h;
参考文献
Whitneys, Simon; Grigg, Ronald; Derrick, Andrew; Keep, Ann
Organic Letters, 2007 , vol. 9, # 17 p. 3299 - 3302
反应条件
1: zinc; aqueous calcium chloride
View Scheme
参考文献
Sabetay; Bleger; de Lestrange
Bulletin de la Societe Chimique de France, 1931 , vol. <4> 49, p. 3,5
反应条件
methanesulfonyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene in tetrahydrofuran
12 h; Ambient temperature;
参考文献
Subramanyam; Noguchi; Weinreb
Journal of Organic Chemistry, 1989 , vol. 54, # 23 p. 5580 - 5585
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine in dichloromethane
T=20°C; 1 h;
参考文献
Kambe, Mika; Arai, Eri; Suzuki, Masashi; Tokuyama, Hidetoshi; Fukuyama, Tohru
Organic Letters, 2001 , vol. 3, # 16 p. 2575 - 2578
反应条件
palladium 10 on activated carbon; hydrogen in ethanol
参考文献
Marti, Almudena; Costero, Ana M.; Gavina, Pablo; Gil, Salvador; Parra, Margarita; Brotons-Gisbert, Mauro; Sanchez-Royo, Juan Francisco
European Journal of Organic Chemistry, 2013 , # 22 p. 4770 - 4779
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane
T=0°C;
参考文献
MERCK and CO., INC.
Patent: WO2005/807 A2, 2005 ;
Location in patent: Page 38 ;
WO 2005/000807 A2
