(S,s)-6-苄基-八氢吡咯并[3,4-b]吡啶双盐酸盐合成路线 （共 13 条）
反应条件
sodium hydroxide in diethyl ether; water T=20 - 35°C; 1 h;
参考文献
WO2009/125425 A2, ;
Page/Page column 6; 10 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=20°C; Reflux; 2: With water; sodium hydroxide in tetrahydrofuran T=30°C;
参考文献
WO2010/100215 A1, ;
Page/Page column 36 ;
反应条件
sodium hydroxide in water
参考文献
WO2003/106450 A1, ;
Page column 55,56 ;
WO 03/106450 A1
反应条件
1: acetic anhydride / toluene 2: hydrogen; ruthenium-carbon composite 3: lithium aluminium tetrahydride / tetrahydrofuran / 10 h / 0 - 5 °C 4: (2S,3S)-2,3-dihydroxybutanedioic acid / ethanol; N,N-dimethyl acetamide; isopropyl alcohol / |Resolution of racemate View Scheme
参考文献
Asian Journal of Chemistry, , vol. 25, # 15 p. 8701 - 8707
反应条件
1: acetic anhydride / toluene 2: hydrogen; ruthenium-carbon composite 3: lithium aluminium tetrahydride / tetrahydrofuran / 10 h / 0 - 5 °C 4: (2S,3S)-2,3-dihydroxybutanedioic acid / ethanol; N,N-dimethyl acetamide; isopropyl alcohol / |Resolution of racemate View Scheme
参考文献
Asian Journal of Chemistry, , vol. 25, # 15 p. 8701 - 8707
反应条件
1: hydrogen; ruthenium-carbon composite 2: lithium aluminium tetrahydride / tetrahydrofuran / 10 h / 0 - 5 °C 3: (2S,3S)-2,3-dihydroxybutanedioic acid / ethanol; N,N-dimethyl acetamide; isopropyl alcohol / |Resolution of racemate View Scheme
参考文献
Asian Journal of Chemistry, , vol. 25, # 15 p. 8701 - 8707
反应条件
1: L-(+)-tartaric acid / |Resolution of racemate 2: sodium hydroxide View Scheme
参考文献
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, , vol. 121, p. 254 - 258
反应条件
Resolution of racemate;
参考文献
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, , vol. 121, p. 254 - 258
反应条件
1: triethylamine / dichloromethane / 20 °C 2: hydrogen / palladium hydroxide on carbon / methanol / 3 h / 20 °C / 1551.49 Torr View Scheme
参考文献
ABBOTT LABORATORIES
Patent: US2011/230459 A1, 2011 ;
