(S,S)-2,8-二氮杂双环[4,3,0]壬烷合成路线 （共 4 条）
反应条件
hydrogen; 5-palladium/activated carbon in methanol T=90°C; P=67506.8 Torr; 5 h;
参考文献
BAYER AKTIENGESELLSCHAFT
Patent: WO2003/106450 A1, 2003 ;
Location in patent: Page column 58 ;
WO 03/106450 A1
反应条件
1: With hydrogen bromide; propionic acid; phenol in water 6 - 7 h; Heating / reflux; 2: With sodium hydroxide in water pH=11 - 12;
参考文献
WANG, Zheqing; FENG, Shushan; CHENG, Yongzhi
Patent: WO2008/85480 A1, 2008 ;
Location in patent: Page/Page column 13-14 ;
反应条件
1: With 5 palladium on charcoal; hydrogen in toluene T=80°C; P=6000.6 Torr; 24 h; 2: With hydrogen bromide; phenol in acetic acid; propionic acid Reflux;
参考文献
Asian Journal of Chemistry, , vol. 25, # 15 p. 8701 - 8707
反应条件
1.1: trifluoroacetic acid; triethylsilane / 4 h / 60 - 65 °C 1.2: 20 °C 2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 25 - 35 °C 3.1: hydrogen; 5 palladium on charcoal / toluene / 24 h / 80 °C / 6000.6 Torr 3.2: |Reflux View Scheme
参考文献
Asian Journal of Chemistry, , vol. 25, # 15 p. 8701 - 8707
