反应条件
1: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, RT, 2 h
2: 1.) lithium cyclohexylisopropylamide / 1.) THF, hexane, from -23 to -20 deg C, 5 h, 2.) THF, hexane, a.) from -23 to -19 deg C, 2 h, b.) RT, overnight
3: 1.) lithium cyclohexylisopropylamide, HMPA / 1.) THF, hexane, from -23 to -19, 5 h, 2.) THF, hexane, a.) from -23 to -14, 2 h, b.) RT, overnight
4: 89 percent / Et3N / CHCl3 / 1 h / Ambient temperature
5: 82 percent / AlCl3, anisole / 0.17 h / 0 °C
6: 81 percent / aq HCl / methanol / 4 h / Heating
7: 84 percent / Fremy's salt, KH2PO4 / H2O; acetone / 0.17 h / Ambient temperature
View Scheme
参考文献
Matsuo; Ishida
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 6 p. 1325 - 1327
