反应条件
1.1: sodium methylate / methanol / 0.5 h / 20 °C
1.2: 2 h / 0 °C
2.1: potassium carbonate / acetone / 8 h / |Reflux
3.1: acetic acid; iron / 1.5 h / 90 °C
4.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / water; 1,4-dioxane / 24 h / |Reflux
5.1: ozone / dichloromethane; methanol / -71 °C
6.1: hydrogen; palladium 10 on activated carbon / dichloromethane; methanol / 7 h / 20 °C / 750.08 Torr
View Scheme
参考文献
KYORIN PHARMACEUTICAL CO., LTD.; MERCK SHARP and DOHME CORP.; FUKUDA, Yasumichi; KAELIN, David E. Jr.; SINGH, Sheo B.
Patent: WO2013/3383 A1, 2013 ;
