3-羟基-4-甲基-2-硝基吡啶合成路线 （共 6 条）
反应条件
hydrazine hydrate; nickel in ethanol 2 h;
参考文献
Kaminski, James J.; Hilbert, James M.; Pramanik, B. N.; Solomon, Daniel M.; Conn, David J.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 11 p. 2031 - 2046
反应条件
potassium carbonate in acetone T=100°C;
参考文献
Lindstroem, Stefan; Ahmad, Tania; Grivas, Spiros
Heterocycles, 1994 , vol. 38, # 3 p. 529 - 540
反应条件
1: With sulfuric acid; nitric acid
T=10 - 20°C; 2 h;
2: With sodium hydroxide
pH=2;
参考文献
SIRTRIS PHARMACEUTICALS, INC.; NG, Pui, Yee; BLUM, Charles; MCPHERSON, Lauren; PERNI, Robert, B.; VU, Chi, B.; AHMED, Mohammed, Mahmood; DISCH, Jeremy, S.
Patent: WO2011/59839 A1, 2011 ;
Location in patent: Page/Page column 85-86 ;
WO 2011/059839 A1
反应条件
1.1: 2 h / Reflux
2.1: potassium hydroxide / methanol / 20 °C
2.2: pH 7
3.1: nitric acid; sulfuric acid / 2 h / 10 - 20 °C
3.2: pH 2
View Scheme
参考文献
SIRTRIS PHARMACEUTICALS, INC.; NG, Pui, Yee; BLUM, Charles; MCPHERSON, Lauren; PERNI, Robert, B.; VU, Chi, B.; AHMED, Mohammed, Mahmood; DISCH, Jeremy, S.
Patent: WO2011/59839 A1, 2011 ;
WO 2011/059839 A1
反应条件
1.1: potassium hydroxide / methanol / 20 °C
1.2: pH 7
2.1: nitric acid; sulfuric acid / 2 h / 10 - 20 °C
2.2: pH 2
View Scheme
参考文献
SIRTRIS PHARMACEUTICALS, INC.; NG, Pui, Yee; BLUM, Charles; MCPHERSON, Lauren; PERNI, Robert, B.; VU, Chi, B.; AHMED, Mohammed, Mahmood; DISCH, Jeremy, S.
Patent: WO2011/59839 A1, 2011 ;
WO 2011/059839 A1
反应条件
potassium hydroxide; sulfuric acid; nitric acid
Yield given. Multistep reaction;
参考文献
Kaminski, James J.; Hilbert, James M.; Pramanik, B. N.; Solomon, Daniel M.; Conn, David J.; et al.
Journal of Medicinal Chemistry, 1987 , vol. 30, # 11 p. 2031 - 2046
