3-羟基-6-甲基-2-硝基吡啶合成路线 （共 17 条）
反应条件
sulfuric acid; nitric acid T=20°C; 2 h;
参考文献
Lindstroem, Stefan; Ahmad, Tania; Grivas, Spiros
Heterocycles, 1994 , vol. 38, # 3 p. 529 - 540
反应条件
sulfuric acid; nitric acid T=20°C; Cooling;
参考文献
GLAXO GROUP LIMITED; ALVARO, Giuseppe; AMANTINI, David
Patent: WO2010/72722 A1, 2010 ;
Location in patent: Page/Page column 34-35 ;
WO 2010/072722 A1
反应条件
1: 99 percent / H2 / Pd/C / ethyl acetate 2: 79 percent / aq. NaHCO3 / butan-2-one 3: 99 percent / lithium aluminum hydride / tetrahydrofuran / 3 h / 20 °C View Scheme
参考文献
Leonard, Kristi; Pan, Wenxi; Anaclerio, Beth; Gushue, Joan M.; Guo, Zihong; DesJarlais, Renee L.; Chaikin, Marge A.; Lattanze, Jennifer; Crysler, Carl; Manthey, Carl L.; Tomczuk, Bruce E.; Marugan, Juan Jose
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 10 p. 2679 - 2684
反应条件
triethylamine in dichloromethane T=0°C; 2 h;
参考文献
PHARMACIA CORPORATION
Patent: WO2004/58761 A1, 2004 ;
Location in patent: Page 52-53; 77 ;
反应条件
hydrogen; palladium on activated charcoal in ethyl acetate
参考文献
3-Dimensional Pharmaceuticals, Inc.
Patent: US2002/169200 A1, 2002 ;
反应条件
potassium carbonate in dimethyl sulfoxide T=20°C;
参考文献
Wyeth
Patent: US2006/173049 A1, 2006 ;
Location in patent: Page/Page column 23-24 ;
US 20060173049 A1
反应条件
in methanol; diethyl ether; dichloromethane
参考文献
Boehringer Ingelheim (Canada) Ltd.
Patent: US2003/236251 A1, 2003 ;
Location in patent: Page 23 ;
参考文献
Kureha Kagaku Kogyo K.K.
Patent: US6610853 B1, 2003 ;
参考文献
Cheng, Cliff C.; Shipps Jr., Gerald W.; Yang, Zhiwei; Sun, Binyuan; Kawahata, Noriyuki; Soucy, Kyle A.; Soriano, Aileen; Orth, Peter; Xiao, Li; Mann, Paul; Black, Todd
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 23 p. 6507 - 6514
反应条件
1: 99 percent / H2 / Pd/C / ethyl acetate
2: 79 percent / aq. NaHCO3 / butan-2-one
View Scheme
参考文献
Leonard, Kristi; Pan, Wenxi; Anaclerio, Beth; Gushue, Joan M.; Guo, Zihong; DesJarlais, Renee L.; Chaikin, Marge A.; Lattanze, Jennifer; Crysler, Carl; Manthey, Carl L.; Tomczuk, Bruce E.; Marugan, Juan Jose
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 10 p. 2679 - 2684
