2-(叔丁氧羰基氨基)-5-己烯酸叔丁酯合成路线 （共 9 条）
反应条件
1: Methyltriphenylphosphonium bromide With potassium tert-butylate in tetrahydrofuran T=0 - 20°C; 1.08333 h; 2: (S)-tert-butyl 2-((tert- butoxycarbonyl)amino)-5-oxopentanoate in tetrahydrofuran T=0 - 20°C;
参考文献
US2012/39848 A1, ;
Page/Page column 97 ;
US 20120039848 A1
反应条件
1: N-Boc-glycine t-butyl ester With N,N,N',N',N'',N''-hexamethylphosphoric triamide; n-butyllithium in tetrahydrofuran T=-78°C; Metallation; 2: 4-bromo-but-1-ene in tetrahydrofuran T=-78 - 20°C; Alkylation; 7.5 h;
参考文献
Adamczyk, Maciej; Johnson, Donald D.; Reddy, Rajarathnam E.
Tetrahedron, 1999 , vol. 55, # 1 p. 63 - 88
反应条件
boron trifluoride diethyl etherate in hexane; dichloromethane 19 h;
参考文献
Biagini, Stefano C. G.; Gibson, Susan E.; Keen, Stephen P.
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 16 p. 2485 - 2499
反应条件
1: 72 percent / NaOH / 1.) H2O, 2.) H2O, tert-BuOH, 18 h 2: 81 percent / BF3*Et2O / hexane; CH2Cl2 / 19 h View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 16 p. 2485 - 2499
反应条件
1: NaOH, H2O / ethanol / 16 h / Heating 2: HCl / H2O 3: 85 percent / NaOH, H2O / 20 h / Heating 4: 72 percent / NaOH / 1.) H2O, 2.) H2O, tert-BuOH, 18 h 5: 81 percent / BF3*Et2O / hexane; CH2Cl2 / 19 h View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 16 p. 2485 - 2499
反应条件
1: 85 percent / NaOH, H2O / 20 h / Heating 2: 72 percent / NaOH / 1.) H2O, 2.) H2O, tert-BuOH, 18 h 3: 81 percent / BF3*Et2O / hexane; CH2Cl2 / 19 h View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 16 p. 2485 - 2499
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane T=20°C; Epoxidation; 17 h;
参考文献
Adamczyk, Maciej; Johnson, Donald D.; Reddy, Rajarathnam E.
Tetrahedron, 1999 , vol. 55, # 1 p. 63 - 88
反应条件
1: With borane-THF in tetrahydrofuran T=0 - 20°C; Addition; 14 h; 2: With sodium hydroxide; dihydrogen peroxide in tetrahydrofuran; water T=0°C; Oxidation; 0.5 h;
参考文献
Adamczyk, Maciej; Johnson, Donald D.; Reddy, Rajarathnam E.
Tetrahedron, 1999 , vol. 55, # 1 p. 63 - 88
反应条件
trifluoroacetic acid in dichloromethane
T=20°C; 5 h;
参考文献
ENANTA PHARMACEUTICALS, INC.; QIU, Yao-Ling; WANG, Ce; PENG, Xiaowen; YING, Lu; CAO, Hui; OR, Yat, Sun
Patent: WO2011/91417 A1, 2011 ;
Location in patent: Page/Page column 84 ;
