4,4,4-三氟-3-三氟甲基丁酸乙酯合成路线 （共 13 条）
反应条件
triethylamine T=20 - 60°C; 2 h;
参考文献
WO2008/9674 A1, ;
Page/Page column 6-7 ;
反应条件
in diethyl ether T=-78.1 - 19.9°C;
参考文献
Arai, Toru; Imachi, Takashi; Kato, Tamaki; Ogawa, H. Iyehara; Fujimoto, Tsutomu; Nishino, Norikazu
Bulletin of the Chemical Society of Japan, 1996 , vol. 69, # 5 p. 1383 - 1389
反应条件
sodium hydride in dimethyl sulfoxide 1) 50 deg C, 12 h, 2) 110 deg C, 2 h;
参考文献
Abele, Herbert; Haas, Alois; Lieb, Max
Chemische Berichte, 1986 , vol. 119, # 111 p. 3502 - 3506
反应条件
boron trifluoride diethyl etherate T=20°C; 48 h;
参考文献
Zaitseva, G. S.; Livantsova, L. I.; Orlova, N. A.; Baukov, Yu. I.; Lutsenko, I. F.
J. Gen. Chem. USSR (Engl. Transl.), 1982 , vol. 52, # 9 p. 2076 - 2084,1847 - 1854
反应条件
pyridine; thionyl chloride
参考文献
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), , # 12 p. 2007 - 2010
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , # 12 p. 2168 - 2172
反应条件
water Yield given. Multistep reaction;
参考文献
Angewandte Chemie, , vol. 92, # 9 p. 740 - 741
反应条件
1: 79 percent / 0.05 Torr / Heating 2: 1) H2O View Scheme
参考文献
Angewandte Chemie, , vol. 92, # 9 p. 740 - 741
参考文献
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), , p. 2002 - 2006
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , # 12 p. 2162 - 2167
反应条件
1: 86 percent / NH3 / diethyl ether / 195 - 293 °C 2: 91 percent / 6M aq. HCl / 7 h / Heating View Scheme
参考文献
Knunyants,I.L.; Cheburkov,Yu.A.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1960 , p. 2002 - 2006
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1960 , # 12 p. 2162 - 2167
反应条件
hydrogen; palladium on activated charcoal
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 9 p. 1282 - 1297
