反应条件
1: 1.) LDA / 1.) cyclohexane, THF, - 78 deg C, 2 h
2: 76 percent / SOCl2, DMF / 1,2-dichloro-ethane / 4 h / Heating
3: 35 percent / NH3 / formamide / 24 h / Ambient temperature
View Scheme
参考文献
Rewcastle, Gordon W.; Palmer, Brian D.; Thompson, Andrew M.; Bridges, Alexander J.; Cody, Donna R.; Zhou, Hairong; Fry, David W.; McMichael, Amy; Denny, William A.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 9 p. 1823 - 1835
