2-溴-3,3,3-三氟丙烯合成路线 （共 51 条）
反应条件
chloro-trimethyl-silane; N,N,N',N,-tetramethylethylenediamine; silver; zinc; tetrakis(triphenylphosphine) palladium(0) 1) THF, 60 deg C, 9 h, 2) 67 deg C, 6 h; Yield given. Multistep reaction;
参考文献
Jiang, Biao; Xu, Yuanyao
Journal of Organic Chemistry, 1991 , vol. 56, # 26 p. 7336 - 7340
反应条件
triethylamine; PdCl2(PPh3) in N,N-dimethyl-formamide T=60°C; P=34200 Torr; 18 h;
参考文献
Fuchikami, Takamasa; Ojima, Iwao
Tetrahedron Letters, 1982 , vol. 23, # 40 p. 4099 - 4100
反应条件
1: 2-Bromo-3,3,3-trifluoro-propene With n-butyllithium; diisopropylamine in diethyl ether T=-78°C; 0.166667 h; 2: formaldehyd in diethyl ether T=-78 - 20°C; 3: With hydrogenchloride in diethyl ether; water
参考文献
BRISTOL-MYERS SQUIBB COMPANY; DHAR, T.G. Murali; XIAO, Hai-Yun; WATTERSON, Scott Hunter; KO, Soo S.; DYCKMAN, Alaric J.; LANGEVINE, Charles M.; DAS, Jagabandhu; CHERNEY, Robert J.
Patent: WO2011/59784 A1, 2011 ;
Location in patent: Page/Page column 79-80 ;
WO 2011/059784 A1
反应条件
(i) nBuLi, (ii) /BRN= 1748614/; Multistep reaction;
参考文献
Drakesmith,F.G. et al.
Journal of Organic Chemistry, 1968 , vol. 33, # 1 p. 280 - 285
反应条件
1: 2-Bromo-3,3,3-trifluoro-propene With ZnCl2*TMEDA; lithium diisopropyl amide in tetrahydrofuran; hexane
T=-78 - 20°C; 1 h;
2: iodobenzene With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; hexane
6 h; Heating;
参考文献
Konno, Tsutomu; Chae, Jungha; Kanda, Masashi; Nagai, Go; Tamura, Kazushige; Ishihara, Takashi; Yamanaka, Hiroki
Tetrahedron, 2003 , vol. 59, # 38 p. 7571 - 7580
反应条件
1: 2-Bromo-3,3,3-trifluoro-propene With ZnCl2*TMEDA; lithium diisopropyl amide in tetrahydrofuran; hexane
T=-78 - 20°C; 1 h;
2: 1-(iodo)-4-methylbenzene With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; hexane
6 h; Heating;
参考文献
Konno, Tsutomu; Chae, Jungha; Kanda, Masashi; Nagai, Go; Tamura, Kazushige; Ishihara, Takashi; Yamanaka, Hiroki
Tetrahedron, 2003 , vol. 59, # 38 p. 7571 - 7580
反应条件
1: 2-Bromo-3,3,3-trifluoro-propene With ZnCl2*TMEDA; lithium diisopropyl amide in tetrahydrofuran; hexane
T=-78 - 20°C; 1 h;
2: para-iodoanisole With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; hexane
6 h; Heating;
参考文献
Konno, Tsutomu; Chae, Jungha; Kanda, Masashi; Nagai, Go; Tamura, Kazushige; Ishihara, Takashi; Yamanaka, Hiroki
Tetrahedron, 2003 , vol. 59, # 38 p. 7571 - 7580
反应条件
1: 2-Bromo-3,3,3-trifluoro-propene With ZnCl2*TMEDA; lithium diisopropyl amide in tetrahydrofuran; hexane
T=-78 - 20°C; 1 h;
2: 1-chloro-4-iodobenzene With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; hexane
6 h; Heating;
参考文献
Konno, Tsutomu; Chae, Jungha; Kanda, Masashi; Nagai, Go; Tamura, Kazushige; Ishihara, Takashi; Yamanaka, Hiroki
Tetrahedron, 2003 , vol. 59, # 38 p. 7571 - 7580
反应条件
triethylamine; bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide
T=100°C; P=30400 Torr; 10 h;
参考文献
Fuchikami, Takamasa; Ojima, Iwao
Tetrahedron Letters, 1982 , vol. 23, # 40 p. 4099 - 4100
反应条件
potassium carbonate; [(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)Pd(1,4-naphthoquinone)]2 in 1,4-dioxane; water
T=90°C; 5 h; Inert atmosphere; Product distribution / selectivity;
参考文献
NISSAN CHEMICAL INDUSTRIES, LTD.
Patent: US2010/160683 A1, 2010 ;
Location in patent: Page/Page column 9 ;
