2-溴-3,3,3-三氟丙烯合成路线 （共 51 条）
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium hydroxide in tetrahydrofuran; ethylene glycol dimethyl ether; water
T=75°C; Suzuki Coupling;
参考文献
Lahm, George P.; Cordova, Daniel; Barry, James D.; Pahutski, Thomas F.; Smith, Ben K.; Long, Jeffrey K.; Benner, Eric A.; Holyoke, Caleb W.; Joraski, Kathleen; Xu, Ming; Schroeder, Mark E.; Wagerle, Ty; Mahaffey, Michael J.; Smith, Rejane M.; Tong, My-Hahn
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 10 p. 3001 - 3006
反应条件
lithium carbonate; triethylamine; bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran
T=100°C; P=7500.75 Torr; 5 h; Product distribution / selectivity;
参考文献
Tosoh F-Tech, Inc.; SAGAMI CHEMICAL RESEARCH CENTER
Patent: EP1637514 A1, 2006 ;
Location in patent: Page/Page column 21 ;
反应条件
potassium hydroxide in ethanol
T=0 - 20°C;
参考文献
Hanamoto, Takeshi; Anno, Ryoko; Yamada, Kenji; Ryu, Kousuke
Tetrahedron Letters, 2007 , vol. 48, # 21 p. 3727 - 3730
参考文献
Henne; Nager
Journal of the American Chemical Society, 1951 , vol. 73, p. 1042
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Haszeldine
Journal of the Chemical Society, 1951 , p. 2495,2503
反应条件
(i) nBuLi, (ii) /BRN= 1748614/; Multistep reaction;
参考文献
Drakesmith,F.G. et al.
Journal of Organic Chemistry, 1968 , vol. 33, # 1 p. 280 - 285
反应条件
1: With n-butyllithium in diethyl ether
T=-78°C; 0.25 h;
2: With methanol in diethyl ether
T=-78°C;
参考文献
Nadano, Ryo; Ichikawa, Junji
Synthesis, 2006 , # 1 art. no. F10205SS, p. 128 - 132
参考文献
Drakesmith,F.G. et al.
Journal of Organic Chemistry, 1968 , vol. 33, # 1 p. 280 - 285
反应条件
1: 2-Bromo-3,3,3-trifluoro-propene With ZnCl2*TMEDA; lithium diisopropyl amide in tetrahydrofuran; hexane
T=-78 - 20°C; 1 h;
2: 4-iodobenzoic acid ethyl ester With tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran; hexane
6 h; Heating;
参考文献
Konno, Tsutomu; Chae, Jungha; Kanda, Masashi; Nagai, Go; Tamura, Kazushige; Ishihara, Takashi; Yamanaka, Hiroki
Tetrahedron, 2003 , vol. 59, # 38 p. 7571 - 7580
反应条件
triethylamine in diethyl ether
T=15 - 25°C;
参考文献
Piotrowski, David W.; Rogers, Bruce N.; McWhorter JR., William W.; Walker, Daniel Patrick; Corbett, Jeffrey W.; Groppi JR., Vincent E.; Rudmann, Daniel G.
Patent: US2003/236287 A1, 2003 ;
Location in patent: Page 49 ;
US 20030236287 A1
反应条件
1: diethyl malonate With potassium fluoride; sodium hydride in N,N-dimethyl-formamide
T=20°C; 0.166667 h;
2: 2-Bromo-3,3,3-trifluoro-propene in N,N-dimethyl-formamide
T=50 - 110°C; 8 h; Further stages.;
参考文献
Jiang, Biao; Zhang, Fangjiang; Xiong, Wennan
Chemical communications (Cambridge, England), 2003 , # 4 p. 536 - 537
