2-氯-2,2-二氟乙酸甲酯合成路线 （共 95 条）
反应条件
N,N'-dimethyl-N,N'-propyleneurea; potassium fluoride; copper(l) iodide heating;
参考文献
MacNeil, James G.; Burton, Donald J.
Journal of Fluorine Chemistry, 1991 , vol. 55, # 2 p. 225 - 228
反应条件
potassium carbonate in ethyl acetate; N,N-dimethyl-formamide
参考文献
SmithKline Beecham Corporation
Patent: US5731477 A1, 1998 ;
反应条件
potassium fluoride; copper(l) iodide; cadmium (II) iodide in N,N,N',N',N'',N''-hexamethylphosphoric triamide T=120°C; 8 h;
参考文献
Chen, Qing-Yun; Duan, Jian-Xing
Tetrahedron Letters, 1993 , vol. 34, # 26 p. 4241 - 4244
反应条件
methanol; zinc T=50°C; 1 - 4 h; Heating / reflux; Product distribution / selectivity;
参考文献
Solvay Fluor GmbH
Patent: EP1574496 A1, 2005 ;
Location in patent: Page/Page column 2; 3 ;
反应条件
potassium fluoride; copper(l) iodide in N,N-dimethyl-formamide T=100°C; 8 h;
参考文献
Su, De-Bao; Duan, Jian-Xing; Chen, Quing-Yun
Tetrahedron Letters, 1991 , vol. 32, # 52 p. 7689 - 7690
反应条件
potassium fluoride; copper(l) iodide in N,N-dimethyl-formamide T=100 - 110°C; 10 h; Yield given;
参考文献
Duan, Jian-Xing; Su, De-Bao; Wu, Jian-Ping; Chen, Qing-Yun
Journal of Fluorine Chemistry, 1994 , vol. 66, # 2 p. 167 - 170
反应条件
in diethyl ether T=-60°C; 4 h;
参考文献
Kitazume, Tomoya; Asai, Masatomo; Tsukamoto, Takashi; Yamazaki, Takashi
Journal of Fluorine Chemistry, 1992 , vol. 56, # 3 p. 271 - 284
反应条件
lithium diisopropyl amide in diethyl ether T=-70°C; 4 h;
参考文献
Kitazume, Tomoya; Asai, Masatomo; Tsukamoto, Takashi; Yamazaki, Takashi
Journal of Fluorine Chemistry, 1992 , vol. 56, # 3 p. 271 - 284
反应条件
N,N,N',N',N'',N''-hexamethylphosphoric triamide; lithium chloride in tetrahydrofuran
参考文献
Wheaton,G.A.; Burton,D.J.
Journal of Organic Chemistry, 1978 , vol. 43, p. 2643 - 2651
反应条件
(i) LiCl, HMPT, (ii) H2O; Multistep reaction;
参考文献
Burton,D.J.; Wheaton,G.A.
Journal of the American Chemical Society, 1974 , vol. 96, p. 6787 - 6788
