3,5-二氟-2-硝基苯酚合成路线 （共 10 条）
反应条件
nitric acid in dichloromethane T=0°C; Inert atmosphere of N2;
参考文献
US2010/120763 A1, ;
Page/Page column 32 ;
US 20100120763 A1
反应条件
sodium hydroxide in water; dimethyl sulfoxide
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1346982 A1, 2003 ;
反应条件
1: With sodium hydroxide in water; dimethyl sulfoxide T=20°C; 20 h; 2: With hydrogenchloride in water pH=5;
参考文献
US2005/176726 A1, ;
Page/Page column 29 ;
US 20050176726 A1
反应条件
nickel(II) ammonium disulfate; nitric acid in dichloromethane T=20°C; 0.5 h;
参考文献
WO2007/67612 A1, ;
Page/Page column 70 ;
WO 2007/067612 A1
反应条件
sodium; boron tribromide in methanol; dichloromethane; water
反应条件
1: HNO3, H2SO4 2: 1.) NaOMe, 2.) BBr3 / 1.) MeOH, 2.) CH2Cl2 View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 9 p. 1362 - 1370
反应条件
sodium hydroxide in dimethyl sulfoxide
参考文献
Magnetic Resonance in Chemistry, , vol. 34, # 6 p. 440 - 446
反应条件
sodium methylate; boron tribromide 1.) MeOH, 2.) CH2Cl2; Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 9 p. 1362 - 1370
反应条件
boron tribromide 1.) methanol, 2 h, 2.) dichloromethane, RT, overnight; Yield given. Multistep reaction;
参考文献
Journal of Pharmacy and Pharmacology, , vol. 45, # 8 p. 736 - 744
反应条件
potassium carbonate in water; N,N-dimethyl-formamide
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1346982 A1, 2003 ;
