甲基(1-甲基吲哚基)-3-乙醛酸酯合成路线 （共 8 条）
反应条件
1: methyl indolyl-3-glyoxylate With sodium hydride in N,N-dimethyl-formamide; mineral oil T=0 - 20°C; 0.5 h; 2: methyl iodide in N,N-dimethyl-formamide; mineral oil T=0 - 20°C; 1 h;
参考文献
Ye, Qing; Li, Meng; Zhou, Yu-Bo; Cao, Jia-Yu; Xu, Lei; Li, Yu-Jin; Han, Liang; Gao, Jian-Rong; Hu, Yong-Zhou; Li, Jia
Archiv der Pharmazie, 2013 , vol. 346, # 5 p. 349 - 358
反应条件
1: diethyl ether / 0.5 h / 0 - 5 °C 2: 2.93 g / diethyl ether; methanol / -65 - 20 °C View Scheme
参考文献
ELI LILLY AND COMPANY
Patent: EP825190 A1, 1998 ;
反应条件
in methanol; diethyl ether T=-65 - 20°C; Esterification;
参考文献
Faul, Margaret M.; Winneroski, Leonard L.; Krumrich, Christine A.
Journal of Organic Chemistry, 1998 , vol. 63, # 17 p. 6053 - 6058
反应条件
sodium methylate in methanol; water; ethyl acetate
参考文献
Gong, Leyi; Grupe, Andrew; Peltz, Gary Allen
Patent: US2002/52397 A1, 2002 ;
US 20020052397 A1
反应条件
1.1: diethyl ether / 1 h / 0 - 5 °C 2.1: methanol / 0.5 h / -30 - 20 °C 3.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C 3.2: 1 h / 0 - 20 °C View Scheme
参考文献
Ye, Qing; Li, Meng; Zhou, Yu-Bo; Cao, Jia-Yu; Xu, Lei; Li, Yu-Jin; Han, Liang; Gao, Jian-Rong; Hu, Yong-Zhou; Li, Jia
Archiv der Pharmazie, 2013 , vol. 346, # 5 p. 349 - 358
反应条件
1.1: methanol / 0.5 h / -30 - 20 °C 2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.5 h / 0 - 20 °C 2.2: 1 h / 0 - 20 °C View Scheme
参考文献
Ye, Qing; Li, Meng; Zhou, Yubo; Pang, Tao; Xu, Lei; Cao, Jiayi; Han, Liang; Li, Yujin; Wang, Weisi; Gao, Jianrong; Li, Jia
Molecules, 2013 , vol. 18, # 5 p. 5498 - 5516
反应条件
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Downie, Ian M.; Earle, Martyn J.; Heaney, Harry; Shuhaibar, Khamis F.
Tetrahedron, 1993 , vol. 49, # 19 p. 4015 - 4034
反应条件
potassium tert-butylate in tetrahydrofuran T=-5 - 45°C;
参考文献
Faul, Margaret M.; Grutsch, John L.; Kobierski, Michael E.; Kopach, Michael E.; Krumrich, Christine A.; Staszak, Michael A.; Udodong, Uko; Vicenzi, Jeffrey T.; Sullivan, Kevin A.
Tetrahedron, 2003 , vol. 59, # 36 p. 7215 - 7229
