反应条件
1: 80 percent / Na / pentan-1-ol / 80 °C / Heating
2: 1.) NEt3, ethylchloroformate / 1.) DMF, 2 deg C, 0.5 h; 2.) DMF, 12 h, RT
3: 93 percent / maleic acid, H2 / 10percent Pd/C / aq. ethanol / 7 h / Ambient temperature
4: 33 percent / K2CO3 / acetone / 36 h / Heating
View Scheme
参考文献
Dostert; Imbert; Langlois; et al.
European Journal of Medicinal Chemistry, 1984 , vol. 19, # 2 p. 105 - 110
