4-氟-2-硝基苯甲酸甲酯合成路线 （共 7 条）
反应条件
sulfuric acid 41 h; Heating / reflux;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2004/54985 A1, 2004 ;
Location in patent: Page 17; 9 ;
反应条件
thionyl chloride in methanol
反应条件
N-methylhexamethylenetetrammonium fluoride in dimethyl sulfoxide T=100°C; 2 h;
参考文献
Journal of Fluorine Chemistry, , vol. 78, # 1 p. 91 - 93
反应条件
tetramethyl-ammonium fluoride in dimethyl sulfoxide T=60°C; 1 h;
参考文献
Journal of the Chemical Society, Chemical Communications, , # 11 p. 921 - 922
反应条件
potassium fluoride; tetra-phenylphosphonium bromide in dimethyl sulfoxide T=130°C; 27 h;
参考文献
Journal of Fluorine Chemistry, , vol. 63, # 1-2 p. 25 - 30
反应条件
potassium carbonate in dimethyl sulfoxide
T=60°C; 7 h; Autoclave;
参考文献
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
Patent: WO2008/28688 A2, 2008 ;
Location in patent: Page/Page column 102 ;
参考文献
Bayer Schering Pharma Aktiengesellschaft
Patent: EP1897885 A1, 2008 ;
