4,7-二溴-2,1,3-苯并噻二唑合成路线 （共 42 条）
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; copper(I) bromide dimethylsulfide complex; Pd[P(o-tol)3]2; caesium carbonate in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=50°C; Inert atmosphereMolecular sieve;
参考文献
Shimizu, Kenta; Minami, Yasunori; Nakao, Yoshiaki; Ohya, Ken-Ichiro; Ikehira, Hideyuki; Hiyama, Tamejiro
Chemistry Letters, 2013 , vol. 42, # 1 p. 45 - 47
反应条件
1: thien-2-yl bromide With iodine; magnesium in tetrahydrofuran
Grignard reaction; 2 h; Inert atmosphereReflux;
2: 4,7-dibromobenzo[c][1,2,5]thiadiazole With [1,3-bis(diphenylphosphino) propane] dichloronickel(II) in tetrahydrofuran
T=20°C; Kumada coupling reaction; 22 h; Inert atmosphereReflux;
参考文献
Sun, Xiaobo; Xu, Xinjun; Qiu, Wenfeng; Yu, Gui; Zhang, Hengjun; Gao, Xike; Chen, Shiyan; Song, Yanlin; Liu, Yunqi
Journal of Materials Chemistry, 2008 , vol. 18, # 23 p. 2709 - 2715
反应条件
tetrakis(triphenylphosphine) palladium(0) in toluene
18 h; Reflux;
参考文献
Li, Yilin; Scudiero, Louis; Ren, Tianhui; Dong, Wen-Ji
Journal of Photochemistry and Photobiology A: Chemistry, 2012 , vol. 231, # 1 p. 51 - 59
反应条件
tetrakis(triphenylphosphine) palladium(0); Aliquatreg; 336; potassium carbonate in water; toluene
Suzuki coupling;
参考文献
Lee, Woochul; Seng, Ji Yeon; Hong, Jong-In
Tetrahedron, 2013 , vol. 69, # 44 p. 9175 - 9182
反应条件
1: With tetrakis(triphenylphosphine) palladium(0); sodium carbonate in ethanol; benzene
T=60 - 80°C; 15 h; Inert atmosphere;
2: With sodium tetrahydroborate; CoCl2.6H2O in tetrahydrofuran; ethanol
T=80°C; 20 h; Inert atmosphere;
参考文献
Dincalp, Haluk; Cimen, Oguzhan; Ameri, Tayebeh; Brabec, Christoph J.; Icli, Siddik
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 2014 , vol. 128, p. 197 - 206
反应条件
1: 99 percent / CsF / NCP-pincer palladacycle / dioxane / 18 h / 130 °C
2: 91 percent / NaBH4; CoCl2*6H2O / ethanol
View Scheme
参考文献
Noujeim, Nadim; Zhu, Kelong; Vukotic, V. Nicholas; Loeb, Stephen J.
Organic Letters, 2012 , vol. 14, # 10 p. 2484 - 2487
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in tetrahydrofuran; water; toluene
Suzuki coupling; 24 h; Heating;
参考文献
Velusamy, Marappan; Thomas, K.R. Justin; Lin, Jiann T.; Hsu, Ying-Chan; Ho, Kuo-Chuan
Organic Letters, 2005 , vol. 7, # 10 p. 1899 - 1902
反应条件
sodium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethanol; benzene
T=85°C; Suzuki coupling; 3.5 h;
参考文献
Ishi-I, Tsutomu; Taguri, Yoshiki; Kato, Shin-Ichiro; Shigeiwa, Motoyuki; Gorohmaru, Hideki; Maeda, Shuuichi; Mataka, Shuntaro
Journal of Materials Chemistry, 2007 , vol. 17, # 31 p. 3341 - 3346
反应条件
tetrakis(triphenylphosphine) palladium(0) in toluene
T=100°C; Stille coupling; 24 h;
参考文献
Liu, Jun; Chen, Lei; Shao, Shiyang; Xie, Zhiyuan; Cheng, Yanxiang; Geng, Yanhou; Wang, Lixiang; Jing, Xiabin; Wang, Fosong
Journal of Materials Chemistry, 2008 , vol. 18, # 3 p. 319 - 327
反应条件
tetrakis(triphenylphosphine) palladium(0); potassium carbonate in water; toluene
Suzuki coupling; 24 h; Inert atmosphereReflux;
参考文献
Dutta, Pranabesh; Yang, Wooseung; Eom, Seung Hun; Lee, Woo-Hyung; Kang, In Nam; Lee, Soo-Hyoung
Chemical Communications, 2012 , vol. 48, # 4 p. 573 - 575
