2-[2-甲基-8-[(4-甲基苯基)磺酰基氨基]喹啉-6-基]氧基乙酸合成路线 （共 6 条）
反应条件
lithium hydroxide in tetrahydrofuran; methanol
Hydrolysis; 4 h; Heating;
参考文献
Fahrni, Christoph J.; O'Halloran, Thomas V.
Journal of the American Chemical Society, 1999 , vol. 121, # 49 p. 11448 - 11458
反应条件
1: 52 percent / aq. HCl; phosphoric acid / 3 h / 95 °C
2: 54 percent / diisopropylethylamine / ethanol / 24 h / Heating
3: 86 percent / H2 / 5 percent Pd/C / ethanol / 24 h / 20 °C
4: 85 percent / pyridine / 20 °C
5: 72 percent / aq. LiOH / tetrahydrofuran; methanol / 4 h / Heating
View Scheme
参考文献
Fahrni, Christoph J.; O'Halloran, Thomas V.
Journal of the American Chemical Society, 1999 , vol. 121, # 49 p. 11448 - 11458
反应条件
1: 54 percent / diisopropylethylamine / ethanol / 24 h / Heating
2: 86 percent / H2 / 5 percent Pd/C / ethanol / 24 h / 20 °C
3: 85 percent / pyridine / 20 °C
4: 72 percent / aq. LiOH / tetrahydrofuran; methanol / 4 h / Heating
View Scheme
参考文献
Fahrni, Christoph J.; O'Halloran, Thomas V.
Journal of the American Chemical Society, 1999 , vol. 121, # 49 p. 11448 - 11458
反应条件
1: 86 percent / H2 / 5 percent Pd/C / ethanol / 24 h / 20 °C
2: 85 percent / pyridine / 20 °C
3: 72 percent / aq. LiOH / tetrahydrofuran; methanol / 4 h / Heating
View Scheme
参考文献
Fahrni, Christoph J.; O'Halloran, Thomas V.
Journal of the American Chemical Society, 1999 , vol. 121, # 49 p. 11448 - 11458
反应条件
1: 85 percent / pyridine / 20 °C
2: 72 percent / aq. LiOH / tetrahydrofuran; methanol / 4 h / Heating
View Scheme
参考文献
Fahrni, Christoph J.; O'Halloran, Thomas V.
Journal of the American Chemical Society, 1999 , vol. 121, # 49 p. 11448 - 11458
反应条件
1: sodium hydride / tetrahydrofuran
2: sodium hydroxide / H2O / 2.5 h / Heating
View Scheme
参考文献
Mahadevan, Indumathy B.; Kimber, Marc C.; Lincoln, Stephen F.; Tiekink, Edward R.T.; Ward, A. David; Betts, W. Henry; Forbes, Ian J.; Zalewski, Peter D.
Australian Journal of Chemistry, 1996 , vol. 49, # 5 p. 561 - 568
