乙基4-苯甲酰基苯甲酸酯合成路线 （共 21 条）
反应条件
1: 4-iodobenzoic acid ethyl ester With lithium di(2,2-dimethyl-2-phenylethyl)cuprate in tetrahydrofuran T=-30 - 20°C; 2: benzoyl chloride in tetrahydrofuran T=20°C;
参考文献
Piazza, Claudia; Knochel, Paul
Angewandte Chemie - International Edition, 2002 , vol. 41, # 17 p. 3263 - 3265
反应条件
Me2NH*BH3; potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in acetonitrile T=25°C; 2 h;
参考文献
Rohbogner, Christoph J.; Clososki, Giuliano C.; Knochel, Paul
Angewandte Chemie - International Edition, 2008 , vol. 47, # 8 p. 1503 - 1507
反应条件
quinoline; 1,10-phenanthroline; tris-(o-tolyl)phosphine; copper(I) bromide in 1-methyl-pyrrolidin-2-one; quinoline T=170°C; 16 h;
参考文献
Goossen, Lukas J.; Rudolphi, Felix; Oppel, Christoph; Rodriguez, Nuria
Angewandte Chemie - International Edition, 2008 , vol. 47, # 16 p. 3043 - 3045
反应条件
1: 4-iodobenzoic acid ethyl ester With isopropylmagnesium chloride in tetrahydrofuran T=-20°C; 2: Benzoyl cyanide With iron (III) acetylacetonate in tetrahydrofuran T=-10°C;
参考文献
Duplais, Christophe; Bures, Filip; Sapountzis, Ioannis; Korn, Tobias J.; Cahiez, Gerard; Knochel, Paul
Angewandte Chemie - International Edition, 2004 , vol. 43, # 22 p. 2968 - 2970
反应条件
1: benzoyl chloride With indium; chloro-trimethyl-silane; ethylene dibromide; lithium chloride in 1-methyl-pyrrolidin-2-one T=40°C; 3 h; Inert atmosphere; 2: ethyl 4-hydroxybenzoate O-trifalte With tris-(dibenzylideneacetone)dipalladium(0) in 1-methyl-pyrrolidin-2-one T=25°C; 6 h; Inert atmosphere;
参考文献
Lee, Dohyung; Ryu, Taekyu; Park, Youngchul; Lee, Phil Ho
Organic Letters, 2014 , vol. 16, # 4 p. 1144 - 1147
反应条件
Me2NH*BH3; potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in acetonitrile T=25°C; 2 h;
参考文献
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN
Patent: WO2008/87057 A1, 2008 ;
Location in patent: Page/Page column 24 ;
反应条件
1: 3-EtO2C-C6H4-I With pentane-1,5-diylbis(magnesium bromide) in tetrahydrofuran T=-78 - 20°C; 1 h; 2: benzoyl chloride in tetrahydrofuran T=20°C; 0.5 h;
参考文献
Yang, Xiaoyin; Knochel, Paul
Synlett, 2004 , # 1 p. 81 - 84
反应条件
1: 4-bromo-benzoic acid ethyl ester With ethylene dibromide; zinc in acetonitrile T=20°C; Electrochemical reaction; 2: benzoyl chloride in acetonitrile T=20°C;
参考文献
Fillon, Hyacinthe; Gosmini, Corinne; Perichon, Jacques
Tetrahedron, 2003 , vol. 59, # 41 p. 8199 - 8202
反应条件
Ni(Br)2(dppe); zinc in tetrahydrofuran T=110°C; 36 h;
参考文献
Huang, Yi-Chun; Majumdar, Kanak Kanti; Cheng, Chien-Hong
Journal of Organic Chemistry, 2002 , vol. 67, # 5 p. 1682 - 1684
反应条件
1: benzoyl chloride With indium; chloro-trimethyl-silane; ethylene dibromide; lithium chloride in tetrahydrofuran; dimethyl sulfoxide T=40°C; 3 h; Inert atmosphere; 2: 4-iodobenzoic acid ethyl ester With tris-(dibenzylideneacetone)dipalladium(0) in tetrahydrofuran; dimethyl sulfoxide T=25°C; 12 h; Inert atmosphere; Reagent/catalystSolventTemperatureTime;
参考文献
Organic Letters, , vol. 16, # 4 p. 1144 - 1147
