2alpha-甲基环丁酮合成路线 （共 28 条）
反应条件
1: tetrahydrofuran; diethyl ether; cyclohexane / -78 °C / Inert atmosphere 2: [bis(acetoxy)iodo]benzene; water / hexafluoroisopropyl alcohol / 0.25 h / 20 °C / Inert atmosphere View Scheme
参考文献
Fujioka, Hiromichi; Komatsu, Hideyuki; Miyoshi, Akihito; Murai, Kenichi; Kita, Yasuyuki
Tetrahedron Letters, 2011 , vol. 52, # 9 p. 973 - 975
反应条件
hydrogen bromide in dichloromethane
T=0°C; 0.0833333 h;
参考文献
Wasserman, Harry H.; Hearn, Michael J.; Cochoy, Robert E.
Journal of Organic Chemistry, 1980 , vol. 45, # 14 p. 2874 - 2880
反应条件
toluene-4-sulfonic acid in dichloromethane
T=0°C; 0.0833333 h;
参考文献
Wasserman, Harry H.; Hearn, Michael J.; Cochoy, Robert E.
Journal of Organic Chemistry, 1980 , vol. 45, # 14 p. 2874 - 2880
反应条件
trifluoroacetic acid sodium salt; trifluoroacetic acid
T=55°C; 120 h;
参考文献
Kuhlman, Thomas S.; Pittelkow, Michael; Solling, Theis I.; Moller, Klaus B.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 8 p. 2247 - 2250
Angew. Chem., 2013 , vol. 125, # 8 p. 2303 - 2306,4
反应条件
sodium carbonate in various solvent(s)
T=60°C; 24 h; Further byproducts given;
参考文献
Collins, Clair J.; Hanack, Michael; Stutz, Herbert; Auchter, Gerhard; Schoberth, Winfried
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5260 - 5268
反应条件
sodium carbonate in various solvent(s)
T=25°C; 720 h;
参考文献
Collins, Clair J.; Hanack, Michael; Stutz, Herbert; Auchter, Gerhard; Schoberth, Winfried
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5260 - 5268
反应条件
sodium carbonate in various solvent(s)
T=80°C; 24 h; Further byproducts given;
参考文献
Collins, Clair J.; Hanack, Michael; Stutz, Herbert; Auchter, Gerhard; Schoberth, Winfried
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5260 - 5268
反应条件
sodium carbonate in various solvent(s)
T=80°C; 24 h; Further byproducts given;
参考文献
Collins, Clair J.; Hanack, Michael; Stutz, Herbert; Auchter, Gerhard; Schoberth, Winfried
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5260 - 5268
反应条件
trifluoroacetic acid sodium salt in trifluoroacetic acid
T=50°C; 264 h;
参考文献
Hanack,M. et al.
Justus Liebigs Annalen der Chemie, 1970 , vol. 733, p. 5 - 26
反应条件
sulfuric acid
0.0833333 h; Ambient temperature; Yield given;
参考文献
Hanack, Michael; Collins, Clair J.; Stutz, H.; Benjamin, Ben M.
Journal of the American Chemical Society, 1981 , vol. 103, # 9 p. 2356 - 2360
