(S)-(+)-1-苯基-2-丙醇合成路线 （共 70 条）
反应条件
Kluyveromyces marxianus CBS 6556 in ethanol T=30°C; 96 h; Microbiological reactionYeast maintenance mediumEnzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Vitale, Paola; Perna, Filippo Maria; Perrone, Maria Grazia; Scilimati, Antonio
Tetrahedron Asymmetry, 2011 , vol. 22, # 23 p. 1985 - 1993
反应条件
formic acid; triethylamine; Pd0-EnCatTM in ethyl acetate T=23°C; 3 h;
参考文献
Ley, Steven V.; Mitchell, Claire; Pears, David; Ramarao, Chandrashekar; Yu, Jin-Quan; Zhou, Wuzong
Organic Letters, 2003 , vol. 5, # 24 p. 4665 - 4668
反应条件
Candida antarctica lipase B in 1,1,1,2-tetrafluoroethane T=25°C; 72 h; Resolution of racemateEnzymatic reaction; optical yield given as percent ee;
参考文献
Ball, Anthony J.; Corr, Stuart; Micklefield, Jason
Tetrahedron Letters, 2009 , vol. 50, # 26 p. 3543 - 3546
反应条件
methanesulfonic acid; (R,R)-dihydroborate in hexane T=-20°C; 48 h; Title compound not separated from byproducts;
参考文献
Imai, Toshiro; Tamura, Tadashi; Yamamuro, Akira; Sato, Tsuneo; Wollmann, Theodor A.; et al.
Journal of the American Chemical Society, 1986 , vol. 108, # 23 p. 7402 - 7404
反应条件
1: bromobenzene With magnesium in tetrahydrofuran T=0°C; 1 h; Inert atmosphere; 2: With copper (I) cyanide in tetrahydrofuran T=-35°C; 0.5 h; 3: (S)-(-)-propylene oxide in tetrahydrofuran T=-35 - 20°C; 1.5 h;
参考文献
Taguri, Tomonori; Yamamoto, Masanobu; Fujii, Toru; Muraki, Yuta; Ando, Tetsu
European Journal of Organic Chemistry, 2013 , # 30 p. 6924 - 6933
反应条件
1: With titanium(IV) isopropylate; (Sa)-2'-[(R)-hydroxy(phenyl)methyl]-(1,1'-binaphthalen)-2-ol in diethyl ether; toluene T=0°C; 1 h; Inert atmosphere; 2: With hydrogenchloride in diethyl ether; water; toluene Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Tetrahedron Asymmetry, , vol. 23, # 10 p. 789 - 794
参考文献
Burgess, Kevin; Jennings, Lee D.
Journal of the American Chemical Society, 1991 , vol. 113, # 16 p. 6129 - 6139
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 2 h; Heating;
参考文献
Talluri, Siva Kumar; Sudalai, Arumugam
Tetrahedron, 2007 , vol. 63, # 39 p. 9758 - 9763
反应条件
1: (-)-(RS,R)-1-chloro-2-phenylethyl p-tolyl sulfoxide With ethyl magnesium chloride in tetrahydrofuran; toluene T=-78°C; 0.8 h; 2: 2,5,5-trimethyl-1,3,2-dioxaborinane in tetrahydrofuran; toluene Heating; 3: With sodium hydroxide; dihydrogen peroxide in various solvents T=0 - 20°C; 3 h;
参考文献
Blakemore, Paul R.; Marsden, Stephen P.; Vater, Huw D.
Organic Letters, 2006 , vol. 8, # 4 p. 773 - 776
反应条件
(1R)-N-oxyl-1-(N-benzylcarbamoyl)-8-azabicyclo[3.2.1]octane; sodium hydrogencarbonate; sodium bromide in dichloromethane; water T=0°C; Electrochemical reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Demizu, Yosuke; Shiigi, Hirofumi; Mori, Hiroyuki; Matsumoto, Kazuya; Onomura, Osamu
Tetrahedron Asymmetry, 2008 , vol. 19, # 23 p. 2659 - 2665
