(S)-(+)-1-苯基-2-丙醇合成路线 （共 70 条）
反应条件
Candida antarctica lipase B; (η5-C5Ph5)Ru(CO)2Cl; potassium tert-butylate; sodium carbonate in tetrahydrofuran; toluene T=20°C; 6 h; Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 127, # 24 p. 8817 - 8825
反应条件
Arthrobacter atrocyaneus in N,N-dimethyl-formamide T=32°C; 72 h; Microbiological reaction; enantioselective reaction;
参考文献
Silva, Camila R.; Souza, Juliana C.; Araujo, Lidiane S.; Kagohara, Edna; Garcia, Thais P.; Pelizzari, Vivian H.; Andrade, Leandro H.
Journal of Molecular Catalysis B: Enzymatic, 2012 , vol. 83, p. 23 - 28
反应条件
1: With 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in dichloromethane T=20°C; Inert atmosphere; 2: With immobilized Candida antarctica Lipase B; water in hexane T=30°C; pH=6.5; 24 h; aq. phosphate bufferEnzymatic reaction; 3: With water; sodium hydroxide in methanol T=20°C; 1 h; optical yield given as percent eeenantioselective reaction;
参考文献
Tetrahedron, , vol. 66, # 40 p. 8060 - 8067
反应条件
Thermoanaerobacter ethanolicus secondary alcohol dehydrogenase W110A; nicotinamide adenine dinucleotide; NADPH in N,N-dimethyl-formamide T=50°C; pH=8; 48 h; Enzymatic reaction; Solvent;
参考文献
Organic and Biomolecular Chemistry, , vol. 11, # 17 p. 2911 - 2915
反应条件
in benzene T=21°C; 10 h; lipase Amano P/Celite 577; Yields of byproduct given;
参考文献
Bianchi, Daniele; Cesti, Pietro; Battistel, Ezio
Journal of Organic Chemistry, 1988 , vol. 53, # 23 p. 5531 - 5534
反应条件
RuCl(η5-C9H7)(PPh3)2; Pseudomonas cepocia lipase; triethylamine T=60°C; Esterification; resolution of racemate; 43 h; Enzymatic reaction; Title compound not separated from byproducts;
参考文献
Koh, Jeong Hwan; Jung, Hyun Min; Kim, Mahn-Joo; Park, Jaiwook
Tetrahedron Letters, 1999 , vol. 40, # 34 p. 6281 - 6284
反应条件
1: With (S)-2-methyl-quinazolinap rhodium; benzo[1,3,2]dioxaborole in tetrahydrofuran T=0°C; 2 h; 2: With sodium hydroxide; dihydrogen peroxide in tetrahydrofuran; ethanol T=0 - 20°C; Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 69, # 20 p. 6572 - 6589
反应条件
1.1: L-proline / dimethylsulfoxide / 2 h / 25 °C 1.2: 86 percent / NaBH4 / dimethylsulfoxide; methanol / 0.17 h / 0 °C 2.1: 88 percent / hydrogen / Pd/C / methanol / 12 h / 760.05 Torr 3.1: triethylamine / CH2Cl2 / 1 h / 0 °C 4.1: 0.33 g / sodium hydride / dimethylformamide; various solvent(s) / 0.5 h / 0 °C 5.1: 92 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 63, # 39 p. 9758 - 9763
反应条件
1: 88 percent / hydrogen / Pd/C / methanol / 12 h / 760.05 Torr 2: triethylamine / CH2Cl2 / 1 h / 0 °C 3: 0.33 g / sodium hydride / dimethylformamide; various solvent(s) / 0.5 h / 0 °C 4: 92 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating View Scheme
参考文献
Tetrahedron, , vol. 63, # 39 p. 9758 - 9763
反应条件
1: baker's yeast / ethanol / 48 h / 25 °C 2: 57 percent / K2CO3 / acetone / 48 h 3: 95 percent / H2 / 10percent Pd/C / ethanol / 48 h View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 7, # 11 p. 3129 - 3134
