(R)-(+)-1-苯基乙醇合成路线 （共 353 条）
反应条件
NaOH buffer; ethylenediaminetetraacetic acid; semisynthetic seleno-subtilisin; 3-mercapto-6-nitro-benzoic acid; citric acid T=25°C; 0.2 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 8, # 6 p. 853 - 856
反应条件
(S)-MeAl(OC6H(CH3)2(C6HCH3)2)2 in diethyl ether; dichloromethane T=-78°C; other reagent; Product distribution;
参考文献
Journal of Organic Chemistry, , vol. 62, # 16 p. 5651 - 5656
反应条件
Candida antarctica B lipase; butan-1-ol in acetonitrile 19.2 h;
参考文献
Swaleh, Sauda M; Hungerhoff, Benno; Sonnenschein, Helmut; Theil, Fritz
Tetrahedron, 2002 , vol. 58, # 20 p. 4085 - 4089
反应条件
1,3-di[(R)-(+)-α-methylbenzyl]imidazolium tetrafluoroborate; potassium tert-butylate in tetrahydrofuran T=-78°C; 1 h; Further byproducts given. Title compound not separated from byproducts;
参考文献
Organic Letters, , vol. 7, # 7 p. 1347 - 1349
反应条件
1,3-di[(R)-(+)-α-methylbenzyl]imidazolium tetrafluoroborate; potassium tert-butylate in tetrahydrofuran T=-78°C; 1 h; Further byproducts given. Title compound not separated from byproducts;
参考文献
Organic Letters, , vol. 7, # 7 p. 1347 - 1349
反应条件
1,3-di[(R)-(+)-α-methylbenzyl]imidazolium tetrafluoroborate; potassium tert-butylate in tetrahydrofuran T=-78°C; 3 h; Further byproducts given. Title compound not separated from byproducts;
参考文献
Organic Letters, , vol. 7, # 7 p. 1347 - 1349
反应条件
1: 39 percent / (+)-(1S,2R)-norephedrine; KOH / [RuCl2(η6-benzene)]2 / propan-2-ol / 20 °C 2: (-)-ephedrine; KOH / [RuCl2(η6-benzene)]2 / propan-2-ol / 20 °C View Scheme
参考文献
Journal of Organometallic Chemistry, , vol. 690, # 13 p. 3176 - 3186
反应条件
1.1: Mg; 1,2-dibromoethane / tetrahydrofuran / 0.5 h / 80 °C 1.2: tetrahydrofuran / 1 h / -78 °C 2.1: MgSO4 / toluene / 20 °C 3.1: H2 / [Rh(cod)2]BF4; (R)-(+)-BINAP / 1,2-dichloro-ethane / 168 h / -20 °C / 6840 Torr 3.2: NaOAc; H2O2 / 2 h / 20 °C View Scheme
参考文献
Journal of Organometallic Chemistry, , vol. 642, # 1-2 p. 145 - 147
反应条件
1.1: MgSO4 / toluene / 20 °C 2.1: H2 / [Rh(cod)2]BF4; (R)-(+)-BINAP / 1,2-dichloro-ethane / 168 h / -20 °C / 6840 Torr 2.2: NaOAc; H2O2 / 2 h / 20 °C View Scheme
参考文献
Journal of Organometallic Chemistry, , vol. 642, # 1-2 p. 145 - 147
反应条件
1: 80 percent / BH3*THF / tetrahydrofuran / 5 h / Ambient temperature 2: 79 percent / pyridine / 4 h / -10 °C 3: 68 percent / LiAlH4 / tetrahydrofuran / 3 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 26, # 1 p. 66 - 71
