(R)-(+)-1-苯基乙醇合成路线 （共 353 条）
反应条件
sodium hydroxide; phosphate buffer; lipase T=20°C; 10 h;
参考文献
Laumen, Kurt; Schneider, Manfred P.
Journal of the Chemical Society, Chemical Communications, 1988 , p. 598 - 600
反应条件
KNO2; 18-crown-6 ether; N,N-dimethyl-formamide in dimethyl sulfoxide T=0°C; 24 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 9, # 4 p. 681 - 689
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C; Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 12, # 12 p. 1801 - 1806
反应条件
Candida antarctica lipase B in various solvent(s) T=28°C; 46 h; Further byproducts given;
参考文献
Gonzalez-Sabin, Javier; Gotor, Vicente; Rebolledo, Francisca
Tetrahedron Asymmetry, 2004 , vol. 15, # 3 p. 481 - 488
反应条件
potassium fluoride; dihydrogen peroxide; potassium hydrogencarbonate in tetrahydrofuran; methanol T=20°C; 16 h; Title compound not separated from byproducts.;
参考文献
Synthesis, , # 21 p. 3631 - 3638
反应条件
1: dimethyl zinc; phenylacetylene With (-)-2-exo-morpholinoisobornane-10-thiol in hexane T=20°C; 0.5 h; Inert atmosphere; 2: benzaldehyde in hexane T=0°C; 13 h; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Wu, Ping-Yu; Wu, Hsyueh-Liang; Shen, Ying-Ying; Uang, Biing-Jiun
Tetrahedron Asymmetry, 2009 , vol. 20, # 16 p. 1837 - 1841
反应条件
1: With 4-(N,N-dimethlyamino)pyridine; dicyclohexyl-carbodiimide in dichloromethane T=20°C; Inert atmosphere; 2: With immobilized Candida antarctica Lipase B; water in hexane T=30°C; pH=6.5; 24 h; aq. phosphate bufferEnzymatic reaction; 3: With water; sodium hydroxide in methanol T=20°C; 1 h; optical yield given as percent eeenantioselective reaction;
参考文献
Tetrahedron, , vol. 66, # 40 p. 8060 - 8067
反应条件
CAL B T=35°C; P=100 Torr; 168 h; Ionic liquidResolution of racemateEnzymatic reaction; optical yield given as percent ee;
参考文献
European Journal of Organic Chemistry, , # 36 p. 6938 - 6943
反应条件
sodium carbonate; Candida rugosa lipase in toluene T=20°C; 144 h; Enzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Merabet-Khelassi, Mounia; Houiene, Zahia; Aribi-Zouioueche, Louisa; Riant, Olivier
Tetrahedron Asymmetry, 2012 , vol. 23, # 11-12 p. 828 - 833
反应条件
sodium hydroxide; phosphate buffer; lipase T=20°C; 10 h;
参考文献
Journal of the Chemical Society, Chemical Communications, , p. 598 - 600
