(R)-(+)-1-苯基乙醇合成路线 （共 353 条）
反应条件
1: 4-(N,N-dimethlyamino)pyridine; triethylamine / dichloromethane / 20 °C 2: lipase B from Candida antarctica; hydrogen / toluene / 48 h / 70 °C / 750.08 Torr / |Resolution of racemate; |Enzymatic reaction View Scheme
参考文献
European Journal of Organic Chemistry, , vol. 2014, # 14 p. 2917 - 2923
反应条件
lipase YS in di-isopropyl ether T=30°C; 19 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 10 p. 1253 - 1256
反应条件
Pseudomonas cepacia lipase in chloroform T=30°C; Esterification; Racemate separation; 55 h; Title compound not separated from byproducts;
参考文献
Synlett, , # 2 p. 225 - 226
反应条件
1: acetophenone With sodium tetrahydroborate in water T=20°C; 2 h; 2: (-)-(R,R)-TADDOL in water 3 h;
参考文献
Enantiomer, , vol. 6, # 1 p. 51 - 55
反应条件
triphenylphosphine; diethylazodicarboxylate in dichloromethane T=-23 - 20°C; Mitsunobu reaction;
参考文献
Tetrahedron Asymmetry, , vol. 13, # 6 p. 615 - 619
反应条件
aluminium trichloride in hexane; toluene T=-5°C; 17 h; Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 13, # 16 p. 1713 - 1719
反应条件
1: 41 percent / t-BuOK / tetrahydrofuran / 52 h / Heating 2: KNO2, 18-crown-6 View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 8, # 13 p. 2189 - 2192
反应条件
benzo[5,6]phenanthro[3,4-h]isoquinoline; N-ethyl-N,N-diisopropylamine in chloroform T=22°C; 68 h; Resolution of racemate; optical yield given as percent ee;
参考文献
Collection of Czechoslovak Chemical Communications, , vol. 74, # 7-8 p. 1151 - 1159
反应条件
Eutypa lata; PDB medium in ethanol T=25°C; 192 h; Microbiological reaction; optical yield given as percent ee;
参考文献
Pinedo-Rivilla, Cristina; Cafeu, Mariana Carrara; Casatejada, Josefina Aleu; Araujo, Angela Regina; Collado, Isidro G.
Tetrahedron Asymmetry, 2009 , vol. 20, # 23 p. 2666 - 2672
反应条件
Trichoderma viride; PDB medium in ethanol T=25°C; 120 h; Microbiological reaction; optical yield given as percent ee;
参考文献
Pinedo-Rivilla, Cristina; Cafeu, Mariana Carrara; Casatejada, Josefina Aleu; Araujo, Angela Regina; Collado, Isidro G.
Tetrahedron Asymmetry, 2009 , vol. 20, # 23 p. 2666 - 2672
