(R)-(+)-1-苯基乙醇合成路线 （共 353 条）
反应条件
1: [Ru(CO)2Cl(C5Bn5)]; potassium tert-butylate / toluene; tetrahydrofuran / |Glovebox 2: 4-(N,N-dimethlyamino)pyridine; pyridine / |Glovebox View Scheme
参考文献
Mavrynsky, Denys; Murzin, Dmitry Yu.; Leino, Reko
ChemCatChem, 2013 , vol. 5, # 8 p. 2436 - 2445
反应条件
sodium hydride in acetonitrile T=20°C; 1.5 h;
参考文献
Journal of Organic Chemistry, , vol. 65, # 26 p. 8893 - 8898
反应条件
[Ru2(p-PriC6H4Me)2(μ-Cl)Cl]2; bis[2-(diphenylphosphino)phenyl] ether in anhydrous xylene T=20 - 150°C; 24.1667 h; Inert atmosphere;
参考文献
Hamid, M. Haniti S. A.; Allen, C. Liana; Lamb, Gareth W.; Maxwell, Aoife C.; Maytum, Hannah C.; et al.
Journal of the American Chemical Society, 2009 , vol. 131, p. 1766 - 1774
反应条件
1: triethylamine; diphenyl phosphoryl azide / toluene / 2 h / 75 °C 2: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethylene glycol dimethyl ether; water / 90 °C / Inert atmosphere 3: water; lithium hydroxide hydrate / methanol / 20 °C 4: sodium hydroxide / ethanol / Industry scale View Scheme
参考文献
WO2011/159550 A2, ;
WO 2011/159550 A2
反应条件
1: triethylamine; diphenyl phosphoryl azide / toluene / 2 h / 75 °C 2: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / ethylene glycol dimethyl ether; water / 90 °C / Inert atmosphere 3: water; lithium hydroxide hydrate / methanol / 20 °C View Scheme
参考文献
AMIDRA PHARMACEUTICALS, INC.; BRITTAIN, Jason, Edward; SEIDERS, Thomas, Jon; KING, Christopher, David
Patent: WO2011/159550 A2, 2011 ;
WO 2011/159550 A2
反应条件
sodium perchlorate; sodium lauryl sulfate in water T=64.5°C; Rate constant;
参考文献
Fritz-Langhals, Elke
Tetrahedron Letters, 1994 , vol. 35, # 12 p. 1851 - 1854
反应条件
[Ir(η5-C5Me5)(C6H4-2-CH2NHCH3)(NCCH3)](PF6); potassium tert-butylate in toluene T=20°C; 17 h; Inert atmosphere;
参考文献
Haak, Robert M.; Berthiol, Florian; Jerphagnon, Thomas; Gayet, Arnaud J. A.; Tarabiono, Chiara; Postema, Christiaan P.; Ritleng, Vincent; Pfeffer, Michel; Janssen, Dick B.; Minnaard, Adriaan J.; Feringa, Ben L.; De Vries, Johannes G.
Journal of the American Chemical Society, 2008 , vol. 130, # 41 p. 13508 - 13509
反应条件
1: 88.6 percent / TeCl4 / CH2Cl2 / 6 h / -50 °C
2: TeCl4 / 3 h / 25 °C
View Scheme
参考文献
Yamauchi, Takayoshi; Hattori, Kaneaki; Mizutaki, Shoichi; Tamaki, Kentaro; Uemura, Sakae
Bulletin of the Chemical Society of Japan, 1986 , vol. 59, p. 3617 - 3620
反应条件
[Fe(III)(TPP)]SbF6 in 1,2-dichloro-ethane
T=80°C; Friedel-Crafts Alkylation; 5 h; Sealed tubeInert atmosphere;
参考文献
Teranishi, Satoru; Kurahashi, Takuya; Matsubara, Seijiro
Synlett, 2013 , vol. 24, # 16 art. no. ST-2013-U0620-L, p. 2148 - 2152
反应条件
1.1: PMe3; DEAD / toluene / 0 - 20 °C
1.2: NaOH / methanol / Heating
2.1: AcOH / Heating
View Scheme
参考文献
Hillier, Michael C.; Desrosiers, Jean-Nicolas; Marcoux, Jean-Francois; Grabowski, Edward J. J.
Organic Letters, 2004 , vol. 6, # 4 p. 573 - 576
