potassium tert-butylate; (η5-C5Ph5)Ru(CO)2Cl in isopropyl alcohol; toluene T=20°C; 1.25 h;

1: [Ru(CO)2Cl(C5Bn5)]; potassium tert-butylate / toluene; tetrahydrofuran / |Glovebox 2: 4-(N,N-dimethlyamino)pyridine; pyridine / |Glovebox View Scheme

1: 94.0 percent Chromat. / Ag2O / (η5-Ph5C5)Ru(CO)(PPh3)Br / toluene / 3 h / 25 °C 2: Novozym-435; air; Ag2O / (η5-Ph5C5)Ru(CO)(PPh3)Br / toluene / 8 h / 25 °C View Scheme

potassium hydroxide; Ru(cymene2)Cl2; L-proline in isopropyl alcohol dependence of yield and enantiomeric excess on structure of the substrate; Product distribution;