反应条件
1: NaBH4 / methanol / -78 °C
2: NaH / dimethylformamide / 2 h / 25 °C
3: 1.) BH3, 2.) pyridinium chlorochromate (PCC) / 1.) THF, 24 deg C, 4 h, 2.) CH2Cl2, 1.5 h
4: tetrahydrofuran / 2 h / 0 - 24 °C
5: hexamethylphosphoric acid triamide / 1 h / 210 °C
6: 1.) BH3 / 1.) THF, 15 deg C, 12 h, 2.) PhMe, 12 atm, 6 h
7: tetrahydrofuran / 3 h / -10 °C
8: SiO2
9: oxone / tetrahydrofuran; H2O / 6 h / 0 °C
10: ethanol / 12 h / 68 °C
11: LDA / tetrahydrofuran / 2 h / 0 - 24 °C
12: Bu4NF / tetrahydrofuran / 7 h / 0 °C
13: MeI / acetonitrile / 1.5 h / 80 °C
14: aq. CuCl2 / tetrahydrofuran / 4 h / 23 °C
15: 2.) AcOH / 1.) THF, from -78 to 0 deg C, 12 h
16: H2 / Pd/C / ethyl acetate / 6 h / 23 °C / 2068.6 Torr
17: 69 percent / aq. NO(KSO3)2, KH2PO4 / acetone / 2 h / 23 °C
View Scheme
参考文献
Falck; Chandrasekhar; Manna, Sukumar; Chiu, Ching-Chen S.; Mioskowski, Charles; Wetzel, Isabelle
Journal of the American Chemical Society, 1993 , vol. 115, # 24 p. 11606 - 11607
