4-甲氧基-N,N-二甲基-苯甲胺合成路线 （共 38 条）
反应条件
1: diethyl ether / 0.25 h / 0 °C
2: bis(1,5-cyclooctadiene)nickel (0); diphenylcyclohexyl phosphine; potassium phosphate / 1,4-dioxane / 24 h / 40 °C / |Inert atmosphere; |Glovebox
View Scheme
参考文献
Maity, Prantik; Shacklady-Mcatee, Danielle M.; Yap, Glenn P. A.; Sirianni, Eric R.; Watson, Mary P.
Journal of the American Chemical Society, 2013 , vol. 135, # 1 p. 280 - 285
反应条件
1: 1.) Ph-S-CH2-Cl 2.) t-BuOK / 2.) THF
2: diethyl ether / 1 h
3: H2, HClO4 / ethyl acetate
4: 70 percent / HF, SbF5 / 0.67 h / 0 °C
View Scheme
参考文献
Berrier, C.; Jacquesy, J. C.; Gesson, J. P.; Renoux, A.
Tetrahedron, 1984 , vol. 40, # 11 p. 1983 - 1994
反应条件
1: 1.) n-BuLi / 1.) ether, room temperature, 2 h, 2.) ether, 0 deg C, 18 h
2: NaHCO3 / benzene / 0.5 h / Ambient temperature
3: dimethylformamide / 12 h
View Scheme
参考文献
Mali; Jagtap; Borse
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1996 , vol. 35, # 2 p. 116 - 120
反应条件
1: 1.) Ph-S-CH2-Cl 2.) t-BuOK / 2.) THF
2: diethyl ether / 1 h
3: H2, HClO4 / ethyl acetate
View Scheme
参考文献
Berrier, C.; Jacquesy, J. C.; Gesson, J. P.; Renoux, A.
Tetrahedron, 1984 , vol. 40, # 11 p. 1983 - 1994
反应条件
1: 1.) Ph-S-CH2-Cl 2.) t-BuOK / 2.) THF
2: 1.) tBuOK / 1.) 0 degC, 2.) 12 hours, ambient temperature
3: H2 / 5percent Pd/C / ethyl acetate / 12 h
View Scheme
参考文献
Berrier, C.; Jacquesy, J. C.; Gesson, J. P.; Renoux, A.
Tetrahedron, 1984 , vol. 40, # 11 p. 1983 - 1994
反应条件
1: 1.) Ph-S-CH2-Cl 2.) t-BuOK / 2.) THF
2: diethyl ether / 1 h
3: H2, HClO4 / ethyl acetate
View Scheme
参考文献
Berrier, C.; Jacquesy, J. C.; Gesson, J. P.; Renoux, A.
Tetrahedron, 1984 , vol. 40, # 11 p. 1983 - 1994
反应条件
1: ethanol
2: NaNH2 / liquid ammonia
View Scheme
参考文献
Berrier, C.; Jacquesy, J. C.; Gesson, J. P.; Renoux, A.
Tetrahedron, 1984 , vol. 40, # 11 p. 1983 - 1994
反应条件
1: 1.) Ph-S-CH2-Cl 2.) t-BuOK / 2.) THF
2: diethyl ether / 1 h
3: H2, HClO4 / ethyl acetate
View Scheme
参考文献
Berrier, C.; Jacquesy, J. C.; Gesson, J. P.; Renoux, A.
Tetrahedron, 1984 , vol. 40, # 11 p. 1983 - 1994
