(3R)-3-羟基-十四烷酸乙酯合成路线 (共 9 条)
反应条件
hydrogen; Ru(II)-R-BINAP in methanol T=100°C; P=5171.62 Torr; 12 h;
参考文献
Burnham Institute for Medical Research; The Texas A and M University System
Patent: US2009/124681 A1, 2009 ;
Location in patent: Page/Page column 11-12; 22 ;
US 20090124681 A1
反应条件
chiral diphenylphosphine-based reagent; hydrogen in ethanol T=50°C; P=37503.8 Torr; Title compound not separated from byproducts.;
参考文献
Karame, Iyad; Bellur, Esen; Rotzoll, Sven; Langer, Peter; Fischer, Christine; Holz, Jens; Boerner, Armin
Synthetic Communications, 2007 , vol. 37, # 7 p. 1067 - 1076
反应条件
copper(l) iodide 1.) THF, -30 deg C, 30 min, 2.) THF, a) -30 deg C, 1 h, b) RT, overnight; Yield givenMultistep reaction;
参考文献
Huang, Guangfei; Hollingsworth, Rawle I.
Tetrahedron Asymmetry, 1998 , vol. 9, # 23 p. 4113 - 4115
参考文献
Ma, Gil; Zancanella, Manuel; Oyola, Yatsandra; Richardson, Robyn D.; Smith, Jeffrey W.; Romo, Daniel
Organic Letters, 2006 , vol. 8, # 20 p. 4497 - 4500
参考文献
Ma, Gil; Zancanella, Manuel; Oyola, Yatsandra; Richardson, Robyn D.; Smith, Jeffrey W.; Romo, Daniel
Organic Letters, 2006 , vol. 8, # 20 p. 4497 - 4500
反应条件
1: DIBAL-H 2: ZnCl2 / CH2Cl2 / 60 h / 20 °C 3: 190 mg / aq. HF / acetonitrile / 7 h / 0 - 23 °C View Scheme
参考文献
Ma, Gil; Zancanella, Manuel; Oyola, Yatsandra; Richardson, Robyn D.; Smith, Jeffrey W.; Romo, Daniel
Organic Letters, 2006 , vol. 8, # 20 p. 4497 - 4500
反应条件
1: DIBAL-H 2: ZnCl2 / CH2Cl2 / 60 h / 20 °C 3: 190 mg / aq. HF / acetonitrile / 7 h / 0 - 23 °C 4: 84 percent / triphenylphosphine; diisopropyl azodicarboxylate / tetrahydrofuran / 0 - 20 °C View Scheme
参考文献
Ma, Gil; Zancanella, Manuel; Oyola, Yatsandra; Richardson, Robyn D.; Smith, Jeffrey W.; Romo, Daniel
Organic Letters, 2006 , vol. 8, # 20 p. 4497 - 4500
反应条件
1: DIBAL-H 2: ZnCl2 / CH2Cl2 / 60 h / 20 °C 3: 190 mg / aq. HF / acetonitrile / 7 h / 0 - 23 °C View Scheme
参考文献
Ma, Gil; Zancanella, Manuel; Oyola, Yatsandra; Richardson, Robyn D.; Smith, Jeffrey W.; Romo, Daniel
Organic Letters, 2006 , vol. 8, # 20 p. 4497 - 4500
反应条件
potassium hydroxide in ethanol
参考文献
Huang, Guangfei; Hollingsworth, Rawle I.
Tetrahedron Asymmetry, 1998 , vol. 9, # 23 p. 4113 - 4115