甲基-2-脱氧-D-呋喃核糖苷二乙酸酯合成路线 （共 8 条）
反应条件
pyridine in dichloromethane T=-30 - 20°C; 7.97 h; Inert atmosphereIndustry scale;
参考文献
WO2012/71508 A1, ;
Page/Page column 4; 9 ;
反应条件
4-(N,N-dimethlyamino)pyridine in pyridine 18 h;
参考文献
Tetrahedron, , vol. 50, # 3 p. 749 - 758
反应条件
1.1: hydrogenchloride / diethyl ether / 20 °C 1.2: 28 h / 20 °C 2.1: pyridine / dichloromethane / 7.97 h / -30 - 20 °C / Inert atmosphere; Industry scale View Scheme
反应条件
1: 0.5percent HCl / 1 h / Ambient temperature 2: pyridine / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 8 p. 1494 - 1497
反应条件
pyridine; hydrogenchloride Yield given. Multistep reaction;
参考文献
Chemistry Letters, , # 7 p. 1187 - 1190
反应条件
sulfuric acid; acetic acid T=6 - 20°C; 5.66 h; Inert atmosphereIndustry scale;
参考文献
JOHNSON MATTHEW PUBLIC LIMITED COMPANY; FU, Xing; ZUMBRUNN, Albercht
Patent: WO2012/71508 A1, 2012 ;
Location in patent: Page/Page column 4; 9-10 ;
反应条件
sulfuric acid; acetic acid T=6 - 20°C; 5.66 h; Inert atmosphereIndustry scale;
参考文献
JOHNSON MATTHEW PUBLIC LIMITED COMPANY; FU, Xing; ZUMBRUNN, Albercht
Patent: WO2012/71508 A1, 2012 ;
Location in patent: Page/Page column 4; 9-10 ;
反应条件
sulfuric acid; acetic acid T=6 - 20°C; 5.66 h; Inert atmosphereIndustry scale;
参考文献
JOHNSON MATTHEW PUBLIC LIMITED COMPANY; FU, Xing; ZUMBRUNN, Albercht
Patent: WO2012/71508 A1, 2012 ;
Location in patent: Page/Page column 4; 9-10 ;
