4-(2-(二乙基氨基)乙氧基)-苯甲醛合成路线 （共 6 条）
反应条件
1: 4-hydroxy-benzaldehyde With potassium carbonate in acetone 2 h; Inert atmosphereReflux; 2: 2-diethylamino-1-chloroethane hydrochloride With potassium iodide in acetone Inert atmosphereReflux;
参考文献
Yadav, Yogesh; MacLean, Erin D.; Bhattacharyya, Annyt; Parmar, Virinder S.; Balzarini, Jan; Barden, Christopher J.; Too, Catherine K.L.; Jha, Amitabh
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 9 p. 3858 - 3866
反应条件
potassium carbonate in acetone T=20°C; 12 h; Heating / reflux;
参考文献
UNIMED PHARMA, SPOL. S R.O.
Patent: WO2008/130332 A1, 2008 ;
Location in patent: Page/Page column 9; 13 ;
反应条件
potassium hydroxide in ethanol 16 h; Heating / reflux;
参考文献
Honold, Konrad; Kaluza, Klaus; Masjost, Birgit; Schaefer, Wolfgang; Scheiblich, Stefan
Patent: US2008/9492 A1, 2008 ;
Location in patent: Page/Page column 17 ;
反应条件
1: 2-diethylamino-1-chloroethane hydrochloride With potassium hydroxide in ethanol 2: benzaldehyde in ethanol 16 h; Heating / reflux;
参考文献
Honold, Konrad; Kaluza, Klaus; Masjost, Birgit; Schaefer, Wolfgang; Scheiblich, Stefan
Patent: US2008/39460 A1, 2008 ;
Location in patent: Page/Page column 14 ;
反应条件
potassium carbonate T=70°C;
参考文献
Amombo, Ghislaine Marlyse Okala; Kramer, Thomas; Lo Monte, Fabio; Goering, Stefan; Fach, Matthias; Smith, Steven; Kolb, Stephanie; Schubenel, Robert; Baumann, Karlheinz; Schmidt, Boris
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 24 p. 7634 - 7640
反应条件
ammonia; hydrogen; RaNi in ethanol T=80°C; P=51683.5 Torr; 12 h;
参考文献
UNIMED PHARMA, SPOL. S R.O.
Patent: WO2008/130332 A1, 2008 ;
Location in patent: Page/Page column 13 ;
